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The analysis of pathological condition in masticatory muscle tendon-aponeurosis hyperplasia using HUMARA assay and immunostaining methods.

Research Project

Project/Area Number 20592344
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionSaitama Medical University

Principal Investigator

YODA Tetsuya  埼玉医科大学, 医学部, 教授 (60242210)

Co-Investigator(Kenkyū-buntansha) SATO Tsuyoshi  埼玉医科大学, 医学部, 講師 (60406494)
SAKATA Yasuaki  埼玉医科大学, 医学部, 講師 (50322425)
安部 貴大  埼玉医科大学, 医学部, 助教 (20383250)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords咀嚼筋腱腱膜過形成症 / クローナリティー解析 / 免疫染色 / 咀嚼筋腱・腱膜過形成症 / Tenomodulin / Smad8 / HUMARA assay / GDF-8 / HUMRA assay / 咀嚼筋腱・腱膜過形成症Tenomodulin
Research Abstract

We calculated seven samples in masticatory muscle tendon-aponeurosis hyperplasia(MATAPHY). We found that both Tenomodulin and Smad8 proteins expressed in MATAPHY's tendon and the proliferation of tendon was a polyclonal fashion. We also demonstrated that collagen 6A1 was upregulated in MATAPHY's tendon by using two dimensional electrophoresis system.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2012 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Proteomic analysis of a masticatory muscle tendon-aponeurosis hyperplasia : a preliminary study using 2D-DIGE system2012

    • Author(s)
      Sato T, Nakamoto A, Hori N, Enoki Y, Fukushima Y, Nakamoto N, Sakata Y, Yamanaka H, Chida D, Abe T, Yoda T
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 咀嚼筋腱腱膜過形成症におけるタンパク質プロファイリング2010

    • Author(s)
      佐藤毅, 中本文, 安部貴, 大堀直子, 中本紀道, 福島洋介, 坂田康彰, 依田哲也
    • Organizer
      第23回日本顎関節学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 咀嚼筋腱腱膜過形成症におけるタンパク質プロファイリング2010

    • Author(s)
      佐藤毅, 中本文, 安部貴大, 堀直子, 中本紀道, 福島洋介, 坂田康彰, 依田哲也
    • Organizer
      第23回日本顎関節学会学術大会
    • Place of Presentation
      東京, 船堀
    • Year and Date
      2010-07-24
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 咀嚼筋腱腱膜過形成症におけるタンパク質プロファイリング2010

    • Author(s)
      佐藤毅
    • Organizer
      第23回日本顎関節学会
    • Place of Presentation
      船堀
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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