Study of osteogenic regeneration using dental follicle cells
| Project/Area Number |
20592347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OGURA Naomi Nihon University, 松戸歯学部, 講師 (10152448)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Ko 日本大学, 松戸歯学部, 助手 (20419758)
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| Research Collaborator |
KONDOH Toshirou 日本大学, 松戸歯学部, 教授 (70178416)
KAMINO Yoshikazu 日本大学, 松戸歯学部, 准教授 (60287662)
AONUMA Haruna 日本大学, 松戸歯学部, 助手(専任扱) (90548306)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯嚢由来細胞 / 未分化間葉系幹細胞 / マイクロアレイ解析 / 石灰化能 / 骨芽細胞分化能 / 骨再生医療応用 / シグナリングパスウェイ解析 / 未分化面葉系幹細胞 / 遺伝子発現解析 / パスウェイ解析 / 骨再生医療 / Microarray解析 / 細胞マーカー / 石灰可能 / alkaline phosphatase / osteomodulin / IGF-II / IGFBP-2 |
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| Research Abstract |
Dental follicle (DFC), which is an ectomesenchymal tissue surrounding the developing tooth germ, contains stem cells and lineage committed progenitor or precursor cells of osteoblasts. In this study, we compared characteristics of DFC and bone marrow mesenchymal stem cells, and analyzed gene expression profiles. DFC are suggested a major source of stem cells in adults, and have great potential for regenerative purposes in cell therapy.
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Report
(4 results)
Research Products
(14 results)
