| Project/Area Number |
20592350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
LI Xianqi Matsumoto Dental University, 総合歯科医学研究所, 講師 (60350831)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Miho 松本歯科大学, 歯学部, 助教 (00444795)
NIWA Takashi 松本歯科大学, 歯学部, 助手 (60507680)
NAKAZAWA Takashi 松本歯科大学, 歯学部, 助手 (50582368)
上松 隆司 松本歯科大学, 大学院・歯科独立研究科, 准教授 (40203476)
楊 淑華 松本歯科大学, 歯学部, 助教 (80360220)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腫瘍ワクチン / OK-432 / サイトカイン / 腫瘍免疫療法 / OK432 / 口腔癌 / Th1細胞 / CTL / CD4+T細胞 / CD4 / CD8 / 癌 / 免疫染色 / ELISA / KLN-205細胞 / 舌癌 |
|---|
| Research Abstract |
Squamous cell cancer cell line (KLN-205 cells) was mixed with OK-432 serviced as OK-432 vaccine. In this research, we used OK-432 vaccine to clarify the mechanisms of antitumor in murine tongue cancer model. The result showed that OK-432 could induce Th1 cytokine production, activated cytotoxic T lymphocyte and macrophage. It is also clear that OK-432 induced strong an antitumor immune response.
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