| Project/Area Number |
20592353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
OGAWARA Katsunori Chiba University, 医学部附属病院, 講師 (20372360)
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| Co-Investigator(Kenkyū-buntansha) |
UZAWA Katsuhiro 千葉大学, 大学院・医学研究院, 准教授 (30302558)
BUKAWA Hiroki 筑波大学, 医学部, 教授 (80173558)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔扁平上皮癌 / Pax Family / マイクロアレイ解析 / リアルタイムPCR法 / 免疫染色法 / Pax family / プロテオーム解析 |
|---|
| Research Abstract |
In the current study, to determine the potential involvement of PAX genes in oral squamous-cell carcinoma (OSCC), we evaluated the status of PAX genes mRNA expression in OSCC cell lines, by real-time quantitative reverse transcriptase-polymerase chain reaction. A significant increase in PAX5 expression was observed in all OSCC-derived cell lines examined compared to human normal oral keratinocytes (HNOKs). The results suggest that PAX5 plays an important role during oral carcinogenesis, and that the gene may have potential as a biomarker and therapeutic target for OSCC.
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