Clinical bone regeneration for indication of implantology by cultivated autologous periosteum.

• Project/Area Number: 20592370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: HOSHINA Hideyuki Niigata University, 医歯学総合病院, 講師 (30173587)
• Co-Investigator(Kenkyū-buntansha): NAGATA Masaki 新潟大学, 医歯学総合病院, 講師 (10242439) ; KAWASE Tomoyuki 新潟大学, 医歯学系, 准教授 (90191999) ; OKUDA Kazuhiro 新潟大学, 医歯学系, 准教授 (00169228) ; UOSHIMA Katsumi 新潟大学, 医歯学系, 教授 (50213400)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 骨膜 / 培養 / 歯槽骨再生 / インプラント / 培養自家骨膜 / PRP / 培養自己骨膜 / 遺伝子多型

Research Abstract

Clinical trial of the alveolar bone regeneration by using the cultivated autologous periosteum (CP) was performed. Clinical outcomes suggested that use of the CP could provide desirable bone augmentation in terms of the quantity and quality.

Research Products

• [Journal Article] The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling. (2011)
  • Author(s): Nagata M, Nuckolls GH, Wang X, Shum L, Seki Y, Kawase T, Takahashi K, Nonaka K, Takahashi I, Noman AA, Suzuki K, Slavkin HC.
  • Journal Title: Bone. 48(4) Pages: 847-856
• [Journal Article] Collagen-Coated Poly(L-lactide-co-epsilon-caprolactone) Film : A Promising Scaffold for Cultured Periosteal Sheets. (2010)
  • Author(s): Kawase T, Yamanaka K, Suda Y, Kaneko T, Okuda K, Kogami H, Nakayama H, Nagata M, Wolff LF, Yoshie H.
  • Journal Title: J Periodontol. 81(11) Pages: 1653-1662
• [Journal Article] Human periosteum-derived cells combined with superporous hydroxyapatite blocks used as an osteogenic bone substitute for periodontal regenerative therapy : an animal implantation study using nude mice. (2010)
  • Author(s): Kawase T. Okuda K, Kogami H, Nakayama H, Nagata M, Sato T, Wolff LF, Yoshie H.
  • Journal Title: J Periodontol. 81(3) Pages: 420-427
• [Journal Article] Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1. (2010)
  • Author(s): Sun X, Suzuki K, Nagata M, Kawauchi Y, Yano M, Ohkoshi S, Matsuda Y, Kawachi H, Watanabe K, Asakura H, Aoyagi Y.
  • Journal Title: Pathol Int. 60(2) Pages: 93-101
• [Journal Article] Osteogenic activity of human periosteal sheets cultured on salmon collagen-coated ePTFE meshes. (2010)
  • Author(s): Kawase T, Okuda K, Nagata M, et al
  • Journal Title: J Mater Sci Mater Med. Volume: 21 Pages: 731-739
  • Peer Reviewed
• [Journal Article] Humm periosteum-derived cells combined with superporous hydroxyapatite blocks used as an osteogenic bone substitute for periodontal regenerative therapy;an animal implantation study using nude mice. (2010)
  • Author(s): Kawase T, Okuda K, Nagata M, et al
  • Journal Title: J Periodontol. Volume: 81 Pages: 420-427
  • Peer Reviewed
• [Journal Article] Collagen-Coated Poly(L-lactide-co-epsilon-caprolactone)Film:A Promising Scaffold for Cultured Periosteal Sheets. (2010)
  • Author(s): Kawase T, Okuda K, Nagata M, et al
  • Journal Title: J Periodontol. Volume: 816 Pages: 1653-1662
  • Peer Reviewed
• [Journal Article] Osteogenic activity of human periosteal sheets cultured on salmon collagen-coated ePTFE meshes. (2010)
  • Author(s): Kawase T, Nagata M, et al
  • Journal Title: J Mater Sci Mater Med. 21 Pages: 731-739
  • Peer Reviewed
• [Journal Article] Human periosteum-derived cells combined with superporous hydroxyapatite blocks used as an osteogenic bone substitute for periodontal regener ative therapy : ananimal implantation study using nude mice. (2010)
  • Author(s): Kawase T, Nagata M, et al
  • Journal Title: J Periodontol. 81 Pages: 420-427
  • Peer Reviewed
• [Journal Article] Osteogenic activity of human periosteal sheets cultured on salmon collagen-coated ePTFE meshes. (2009)
  • Author(s): Kawase T, Okuda K, Kogami H, Nakayama H, Nagata M, Yoshie H.
  • Journal Title: J Mater Sci Mater Med. 21(2) Pages: 731-739
• [Journal Article] Characterization of human cultured periosteal sheets expressing bone-forming potential : in vitro and in vivo animal studies. (2009)
  • Author(s): Kawase T, Okuda K, Kogami H, Nakayama H, Nagata M, Nakata K, Yoshie H.
  • Journal Title: J Tissue Eng Regen Med. 3(3) Pages: 218-229
• [Journal Article] A local bone anabolic effect of rhFGF2-impregnated gelatin hydrogel by promoting cell proliferation and coordinating osteoblastic differentiation (2009)
  • Author(s): Kodama N., Nagata M., et al.
  • Journal Title: BONE 44 Pages: 699-707
  • Peer Reviewed
• [Journal Article] Characterization of human cultured periosteal sheets expressing bone-forming potential : in vitro and in vivo animal studies (2009)
  • Author(s): Kawase T., et al.
  • Journal Title: J Tissue Eng Regen Med. (In press)
  • Peer Reviewed
• [Journal Article] 培養自家骨膜を用いた歯槽骨 増生によるインプラント治療の適応拡大 (2008)
  • Author(s): 永田昌毅
  • Journal Title: ザクインテッセンス Vo127(9) Pages: 58-61
• [Presentation] コンビユーターガイドシステムによる口腔インプラント治療の経験. (2010)
  • Author(s): 山田一穂, 星名秀行, 勝見祐二, 荒澤恵, 嵐山貴徳, 魚島勝美, 高木律男
  • Organizer: 日本形成外科学会関東支部 第83回新潟地方会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-07-05
• [Presentation] 自家骨移植による上顎洞底挙上術後の移植骨体積の経時的変化. (2010)
  • Author(s): 荒澤恵, 小田陽平, 小林正治, 魚島勝美, 西山秀昌, 星名秀行, 齋藤力
  • Organizer: 第14回顎顔面インプラント学会, 大会長賞.
  • Place of Presentation: 浦安市
• [Presentation] 培養自家骨細胞を併用した歯槽骨再生療法のインプラント症例における臨床的検討. (2010)
  • Author(s): 永田昌毅, 星名秀行, 荒沢恵, 上松晃也, 嵐山貴徳, 勝見祐二, 高木律男
  • Organizer: 第55回(社)日本口腔外科学会総会・学術大会, 優秀ポスター発表賞
  • Place of Presentation: 千葉市
• [Presentation] 培養自家骨細胞を併用した歯槽骨再生療法のインプラント症例における臨床的検討 (2010)
  • Author(s): 永田昌毅, 星名秀行, 他
  • Organizer: 第55回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉市
• [Presentation] 歯科インプラント適応を目的とした培養自家骨膜併用による歯槽骨再生. (2009)
  • Author(s): 永田昌毅, 川瀬知之, 奥田一博, 中田光, 吉江弘正, 高木律男
  • Organizer: 第52回秋季日本歯周病学会学術集会
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-10-11
• [Presentation] 歯科インプラント適応を目的とした培養自家骨膜併用による歯槽骨再生 (2009)
  • Author(s): 永田昌毅、川瀬知之, 他
  • Organizer: 第52回秋季日本歯周病学会学術集会
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-10-11
• [Presentation] コンピュータガイドシステムを用いたインプラント埋入の臨床的検討. (2009)
  • Author(s): 山田一穂, 荒井良明, 星名秀行, 嵐山貴徳, 荒澤恵, 山田裕士, 三上諭, 魚島勝美
  • Organizer: 平成21年度新潟歯学会第1回例会.
  • Place of Presentation: 新潟市
  • Year and Date: 2009-07-18
• [Presentation] 歯科インプラントを日的とした培養自家骨膜併用による歯槽骨再生. (2009)
  • Author(s): 永田昌毅, 星名秀行, 川瀬知之, 荒澤恵, 山田一穂, 嵐山貴徳, 中田光, 高木律男
  • Organizer: 日本形成外科学会関東支部 第80回新潟地方会.
  • Place of Presentation: 新潟市
  • Year and Date: 2009-07-13
• [Presentation] インプラントに関連した上顎洞合併症の臨床的検討. (2009)
  • Author(s): 星名秀行, 池田順行, 高木律男, 嵐山貴徳, 山田一穂, 荒澤恵, 魚島勝美
  • Organizer: 第39回(社)日本口腔インプラント学会.
  • Place of Presentation: 大阪
• [Presentation] 下顎枝骨に培養骨膜細胞を併用し上顎洞底挙上術を施行した3例 (2008)
  • Author(s): 星名秀行, 永田昌毅, 荒澤恵, 山田裕士, 吉田恵子, 荒井良明, 魚島勝美, 高木律男
  • Organizer: 第38回(社)日本口腔インブラント学会
  • Place of Presentation: 東京
• [Presentation] Evidence to support the clinical application of cultured human periodontal sheets : Evaluation of its bone-forming potential. (2008)
  • Author(s): Kawase T, Okuda K, Kogami H, Nakata M, Nakata K, Yoshie H.
  • Organizer: 2008 American Academy of Periodontology Annual Meeting(2008 ACADEMY AWARD for Research forum poster Session)
  • Place of Presentation: Seattle, WA, USA
• [Presentation] Evidence to support the clinical application of cultured human Periodontal sheets : Evaluation of its bone-forming potential (2008)
  • Author(s): Kawase T., et al.
  • Organizer: American Academy of Periodontology Annual Meeting
  • Place of Presentation: Seattle, WA, USA
• [Book] 「培養自家骨膜を用いた歯槽骨増生によるインプラント治療の適応拡大」ザクインテッセンス vol27, no9, p58-61 (2009)
  • Author(s): 永田昌毅
  • Publisher: ザクインテッセンス
• [Remarks] ホームページ等
• [Remarks] 学会発表では優秀発表賞を受賞した。