The role of substance P in analgesia and immobility induced by general anesthetic agents
| Project/Area Number |
20592373
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
IRIFUNE Masahiro Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (10176521)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Keywords | 全身麻酔作用 / 脊髄後根神経節(DRG)細胞 / サブスタンスP / 正向反射 / 侵害刺激による体動の抑制(不動化) / 鎮痛作用 / 脊髄後根神経節(DRG) / α2-アドレナリン受容体作動薬 / オピオイド受容体作動薬 / 不動化 / GABA / グリシン取り込み阻害薬 |
|---|
| Research Abstract |
The role of substance P (SP) in general anesthetic action was examined. In in vivo study, general anesthetic action was evaluated in mice using an anesthetic end point : loss of movement in response to noxious stimulation (as a measure of immobility). In in vitro SP release study, primary afferent neurons prepared from Wistar rat dorsal root ganglion (DRG) cells were cultured. Morphine is known to inhibit SP release from primary afferent neurons. The ED_95 of morphine of analgesia significantly enhanced immobility induced by pentobarbital, an intravenous anesthetic agent. Pentobarbital suppressed the SP release evoked by capsaicin in a concentration-dependent fashion. These findings suggest that the pentobarbital-induced immobility may involve the suppression of SP release from primary afferent neurons.
|
Report
(4 results)
Research Products
(14 results)
-
-
[Presentation] ペントバルビタールが引き起こす麻酔要素に及ぼすGABA,グリシンおよび神経性ニコチン受容体リガンドの影響2010
Author(s)
向井明里, 入舩正浩, 宮原岳史, 大植香菜, 土井充, 清水慶隆, 齊田拓也, 三浦完菜, 西中村亮, 福島怜子
Organizer
第38回日本歯科麻酔学会総会・学術集会
Place of Presentation
横須賀
Year and Date
2010-10-08
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
