| Project/Area Number |
20592379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SAKURAI Satoru Tokyo Dental College, 歯学部, 講師 (50225843)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAWAKI Takuya 岡山大学, 医歯(薬)学総合研究科, 教授 (00219825)
|
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| Co-Investigator(Renkei-kenkyūsha) |
ICHINOHE Tatsuya 東京歯科大学, 歯学部, 教授 (40184626)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
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| Keywords | アミノフィリン / アデノシン / 鎮静・催眠作用 / 回復 / 鎮静作用 |
|---|
| Research Abstract |
Sedative/hypnotic effect of midazolam involved Gamma-aminobutyric acid receptor.Moreover, midazolam increases adenosine level in Central Nervous System. Since adenosine receptors are involved in natural sleep, sedation/ hypnosis occurs by adenosine increase in Central Nervous System. Aminophylline, an adenosine receptor antagonist, reversed sedative effects of midazolam. Reversal effects by aminophylline may be mediated by antagonistic actions at adenosine receptors. Thus adenosine receptor may be involved in sedation/hypnotic effect of midazolam.
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