| Project/Area Number |
20592380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
NASHIDA Tomoko The Nippon Dental University, 新潟生命歯学部, 准教授 (10133464)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Akane 日本歯科大学, 新潟生命歯学部, 准教授 (60180080)
SHIMOMURA Hiromi 日本歯科大学, 新潟生命歯学部, 教授 (40139259)
YOSHIE Sumio 日本歯科大学, 新潟生命歯学部, 教授 (30095278)
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| Co-Investigator(Renkei-kenkyūsha) |
IGARASHI Atsuko 新潟大学, 大学院・医歯学総合研究科, 准教授 (90168097)
SATO Ritsuko 日本歯科大学・新潟短期大学, 准教授 (50178787)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 唾液腺 / 口腔乾燥症 / 唾液 / NODマウス / プロテオーム解析 / マイクロアレイ解析 / DNAマイクロアレイ解析 / リアルタイムPCR / アクアポリン / 糖尿病 |
|---|
| Research Abstract |
We determined the proteins showing characteristic expression in parotid glands from non-obese diabetic (NOD) mouse which shows autoimmune diabetes and is used as a model for Sjogren syndrome. Chitinase was selected by cDNA microarray analysis as a characteristic secretory protein. Chitinase was expressed in the parotid glands and secreted in saliva. After diabetes onset, the expression of chitinase was increased in the parotid glands and the concentration of chitinase in saliva was increased.
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