Reverification of the mechanistic membrane effects of anesthetics : Interactions with biomembrane rafts and specific membrane lipids
| Project/Area Number |
20592381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
TSUCHIYA Hironori Asahi University, 歯学部, 教授 (30131113)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGAMI Maki 朝日大学, 歯学部, 准教授 (10231614)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 麻酔薬 / 作用機序 / 生体膜 / 相互作用 / ラフト / 膜脂質 / 膜流動性 / 心毒性 / 薬物立体構造 / 構造特異性 / 薬理学的機序 / 構造-膜活性相関 / 局所麻酔薬 / 生体膜相互作用 / 膜流動性変化 / 脂質組成 / 麻酔作用と心毒性 / 効果減弱と炎症 / 脂質過酸化 |
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| Research Abstract |
Apart from the conventional mechanism in which anesthetics specifically bind to receptors and channels, we reverified the mechanistic hypothesis that anesthetics may interact with biomembranes to exert clinically useful and adverse effects based on the latest structural and functional theory about biomembranes. The relevance of membrane lipid rafts to anesthetics was questionable at least in their effects on raft-like model membranes. However, anesthetics structure-dependently interacted with biomimetic membranes consisting of specific lipids (cholesterol and anionic phospholipids) and their interacting potencies were discriminated even between stereoisomers. These results support the membrane interaction of anesthetics as the mode of action.
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Report
(5 results)
Research Products
(53 results)
