The mechanisms of enhanced cardioprotection by combination of volatile anesthetics and moderate alcohol consumption
| Project/Area Number |
20592382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
MIYAMAE Masami Osaka Dental University, 歯学部, 講師 (20298821)
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| Co-Investigator(Kenkyū-buntansha) |
DOMAE Naochika 大阪歯科大学, 歯学部, 名誉教授 (60115889)
SUGIOKA Shingo 大阪歯科大学, 歯学部, 講師 (90278573)
KOTANI Junichiro 大阪歯科大学, 歯学部, 教授 (40109327)
KANEDA Kazuhiro 大阪歯科大学, 歯学部, 研究員 (90533886)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アルコール / 一酸化窒素合成酵素 / 心臓 / 虚血 / モルモット / セボフルラン / sevoflurane / ethanol / heart / ischemia / guinea pig / mPTP / GSK3β / apoptosis / alcohol / nitric oxide synthase / nitric oxide |
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| Research Abstract |
Sevoflurane enhances cardiac preconditioning induced by moderate ethanol consumption. This effect is associated with glycogen synthase kinase 3ss phosphorylation and inhibition of mitochondrial permeability transition pore opening.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Acute memory phase of sevoflurane preconditioning is associated with sustained translocation of protein kinase C-alpha and epsilon, but not delta, in isolated guinea pig hearts.2009
Author(s)
OKUSA C, MIYAMAE M, SUGIOKA S, KANEDA K, INAMIRA Y, ONISHI A, DOMAE N, KOTANI J, FIGUEREDO VM
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Journal Title
Eur J Anaesthesiol 26
Pages: 582-588
Related Report
Peer Reviewed
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[Journal Article] Sevoflurane enhances ethanol-induced cardiac preconditioning through modulation of protein kinase C, mitochondrial KATP channels, and nitric oxide synthase, in guinea pig hearts.2008
Author(s)
KANEDA K, MIYAMAE M, SUGIOKA S, OKUSA C, INAMURA Y, DOMAE N, KOTANI J, FIGUEREDO VM
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Journal Title
Anesth Analg 106
Pages: 9-15
Related Report
Peer Reviewed
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[Presentation] Cardioprotection by regular ethanol consumption is mediated through the bradykinin B2 receptor through increased nitric oxide production.2010
Author(s)
KANEDA K, MIYAMAE M, SUGIOKA S, OKUSA C, INAMURA Y, ONISHI A, SHIOMI M, OKAMURA S, DOMAE N, FIGUEREDO VM, KOTANI J
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago, USA
Year and Date
2010-11-17
Related Report
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[Presentation] ジピリダモール,セボフルラン,NO供与薬による心筋プレコンディショニングの比較および相互作用2010
Author(s)
大草知佳,宮前雅見,杉岡伸悟,金田一弘,稲村吉高,大西杏奈,塩見真由美,岡村静,堂前尚親,小谷順一郎
Organizer
第38回日本歯科麻酔学会総会・学術集会
Place of Presentation
横須賀芸術劇場(神奈川県)
Year and Date
2010-10-09
Related Report
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[Presentation] モルモット口腔内侵害刺激における脳波変化と三叉神経脊髄路核におけるpERKの発現2010
Author(s)
杉岡伸悟,宮前雅見,松田佳子,讃岐拓郎,金田一弘,大草知佳,稲村吉高,大西杏奈,塩見真由美,岡村静,堂前尚親,小谷順一郎
Organizer
第38回日本歯科麻酔学会総会・学術集会
Place of Presentation
横須賀芸術劇場(神奈川県)
Year and Date
2010-10-08
Related Report
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