Novel bone tissue engineering method using PTH signaling, its application to secondary alveolar bone grafting in patients with CLP and orthodontic evaluation
| Project/Area Number |
20592387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUSAMI Takafumi The University of Tokyo, 医学部附属病院, 准教授 (80179184)
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| Co-Investigator(Kenkyū-buntansha) |
OHKUBO Kazumi 東京大学, 医学部附属病院, 助教 (10396715)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
OGATA Naoshi 東京大学, 医学部附属病院, 講師 (10361495)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 顎裂部骨移植 / 副甲状腺ホルモン / 歯科矯正学 |
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| Research Abstract |
This study was conducted to (1) make tissue-engineered bone by using parathyroid hormone (PTH), (2) elucidate the mechanism of PTH function in bone formation and (3) evaluate the quality as a material for bone grafting of the tissue-engineered bone constructed by this novel method in terms of orthodontics. As a result, PTH was found to be able to promote bone formation and bone differentiation both in vivo and in vitro. It was suggested that use of PTH or suppression of Gαq signaling may be effective to produce tissue-engineered bone which could be applied to secondary alveolar bone grafting.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Transforming growth factor-β1 in combination with fibroblast growth factor-2 and insulin-like growth factor-I for chondrocyte proliferation culture and cartilage regenerative medicine.2009
Author(s)
Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung UI, Yoda T, Mori Y, Susami T, Takato T, Hoshi K.
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Journal Title
Asian J Oral Maxillofac Surg 21
Pages: 18-26
Related Report
Peer Reviewed
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[Journal Article] Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER : identification of sorting nexin 19 as a novel factor.2009
Author(s)
Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.
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Journal Title
Arthritis Rheum. 60(11)
Pages: 3314-23
Related Report
Peer Reviewed
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[Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.2009
Author(s)
Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
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Peer Reviewed
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[Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.2008
Author(s)
Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
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Journal Title
J Biol Chem. 283
Pages: 24682-689
Related Report
Peer Reviewed
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[Presentation] 片側顎裂に対する二次的骨移植-術後早期の評価と成長終了後の評価-2009
Author(s)
大久保和美, 須佐美隆史, 松崎雅子, 長濱浩平, 飯野光善, 森良之, 近津大地, 西條英人, 大木明子, 引地尚子, 高戸毅
Organizer
第33回日本口蓋裂学会総会・学術集会
Place of Presentation
東京都千代田区
Related Report
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