| Project/Area Number |
20592387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUSAMI Takafumi The University of Tokyo, 医学部附属病院, 准教授 (80179184)
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| Co-Investigator(Kenkyū-buntansha) |
OHKUBO Kazumi 東京大学, 医学部附属病院, 助教 (10396715)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
OGATA Naoshi 東京大学, 医学部附属病院, 講師 (10361495)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 顎裂部骨移植 / 副甲状腺ホルモン / 歯科矯正学 |
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| Research Abstract |
This study was conducted to (1) make tissue-engineered bone by using parathyroid hormone (PTH), (2) elucidate the mechanism of PTH function in bone formation and (3) evaluate the quality as a material for bone grafting of the tissue-engineered bone constructed by this novel method in terms of orthodontics. As a result, PTH was found to be able to promote bone formation and bone differentiation both in vivo and in vitro. It was suggested that use of PTH or suppression of Gαq signaling may be effective to produce tissue-engineered bone which could be applied to secondary alveolar bone grafting.
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