| Project/Area Number |
20592389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOIKE Mariko Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (50376779)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Yoshiro 東京医科歯科大学, 医歯学総合研究科, 講師 (20292980)
KANEKO Sawa 東京医科歯科大学, 医歯学総合研究科, 助教 (80372449)
HOSOMICHI Jyun 東京医科歯科大学, 医歯学総合研究科, 助教 (00420258)
WATARI Ippei 東京医科歯科大学, 医歯学総合研究科, 助教 (10431941)
小野 法明 東京医科歯科大学, 歯学部附属病院, 医員 (20451908)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 老化 / 骨リモデリング / 歯周組織 / 骨リモデルング / bFGF / 歯学 / 細胞・組織 / 矯正 / mcchanical stress / 神経ペプチド / CGRP |
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| Research Abstract |
The changes in periodontal tissue with growth and aging were analyzed. The expression of CGRP-ir nerve fibers in the PDL is most active in the growth period and decreases gradually with aging. Moreover, age-related decreases in the expression of bFGF may delay the regeneration of the periodontal ligament. Such an effect may act unfavorably in the case of tooth movement.
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