| Project/Area Number |
20592390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KANEKO Sawa Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (80372449)
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| Co-Investigator(Kenkyū-buntansha) |
KANNO Zuisei 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (40345301)
KOIKE Mariko 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50376779)
HOSOMICHI Jun 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00420258)
WATARI Ippei 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (10431941)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨性癒着 / 歯根膜 / 再生 / in vivo electroporation / 石灰化抑制因子 / 再植 |
|---|
| Research Abstract |
To elucidate the pathophysiology of periodontal ligament in the ankylosed tooth at a molecular cell level, we revealed patterns of expression of IGF-1 (cell growth factor) , bFGF (fibroblast growth factor) and VEGF (vascular endothelial growth factor) using by occlusal hypofunction model in rat molars region. We also examined effects of SNS(sympathetic nervous system)/ovariectomy on alveolar bone loss induced by occlusal hypofunction in rats, because the pathophysiology of the ankylosed tooth was much concerned to alveolar bone remodeling.
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