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Study on the control system of the physiological root resorption which might be present in the deciduous root dentin

Research Project

Project/Area Number 20592392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKAGI Yuuzou  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (30124697)

Co-Investigator(Kenkyū-buntansha) SHIOKAWA Hitoyata  東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (80014257)
MIYASHIN Michiyo  東京医科歯科大学, 歯学部附属病院, 助教 (90229849)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords乳歯 / 生理的歯根吸収 / 破骨細胞 / 象牙質有機基質 / 吸収抑制 / 象牙質 / 歯根吸収 / TRAP / TCF-β / BMP-2 / 非コラーゲン性基質 / 吸収活性 / TGF-β / 非コラーゲン性有機基質 / c-Srcリン酸化活性 / 破骨細胞マーカー遺伝子
Research Abstract

Some factors that suppress osteoclast activity are contained in both deciduous and permanent dentin organic matrix extracts. Although there was no significant difference in osteoclast activity between deciduous and permanent dentin extracts, osteoclasts incubated with permanent dentin extracts tend to exhibit less resorption activity than those incubated with deciduous dentin extracts.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Bovine dentine organic matrix down-regulates osteoclast activity.2009

    • Author(s)
      Sriarj W., Aoki K., Ohya K., Takagi Y., Shimokawa H.
    • Journal Title

      J.Bone Mineral and Metabolism 27

      Pages: 315-323

    • NAID

      10025337365

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bovine dentine organic matrix down-regulates osteoclast activity2009

    • Author(s)
      W.Sriarj, K.Aoki, K.Ohya, Y.Takagi, H.Shimokawa
    • Journal Title

      J.Bone Mineral and Metabolism 27

      Pages: 315-323

    • NAID

      10025337365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Factors in dentine organic matrices influence osteoclastogenesis2010

    • Author(s)
      Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H
    • Organizer
      IADR 88^<th> General Session
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Dentin organic matrices effect on osteoclastogenesis.2008

    • Author(s)
      Sriarj W., Aoki K., Ohya K., Takagi Y., Shimokawa H.
    • Organizer
      IADR 86^<th> General Session
    • Place of Presentation
      Tronto, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Dentin organic matrices effect on osteoclastogenesis.2008

    • Author(s)
      Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H.
    • Organizer
      lADR 86^<th> General Session
    • Place of Presentation
      Tronto, Canada
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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