| Project/Area Number |
20592392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAGI Yuuzou Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (30124697)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOKAWA Hitoyata 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (80014257)
MIYASHIN Michiyo 東京医科歯科大学, 歯学部附属病院, 助教 (90229849)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 乳歯 / 生理的歯根吸収 / 破骨細胞 / 象牙質有機基質 / 吸収抑制 / 象牙質 / 歯根吸収 / TRAP / TCF-β / BMP-2 / 非コラーゲン性基質 / 吸収活性 / TGF-β / 非コラーゲン性有機基質 / c-Srcリン酸化活性 / 破骨細胞マーカー遺伝子 |
|---|
| Research Abstract |
Some factors that suppress osteoclast activity are contained in both deciduous and permanent dentin organic matrix extracts. Although there was no significant difference in osteoclast activity between deciduous and permanent dentin extracts, osteoclasts incubated with permanent dentin extracts tend to exhibit less resorption activity than those incubated with deciduous dentin extracts.
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