| Project/Area Number |
20592404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FUJIHARA Shinji The University of Tokushima, 病院, 助教 (70403706)
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Shinya 徳島大学, 病院, 助教 (70263861)
IZAWA Takashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (30380017)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 歯学 / ペリオスチン / アポトーシス / シグナル伝達 / Periostin / 骨芽細胞 / 歯根膜線維芽細胞 |
|---|
| Research Abstract |
In this study, we examined the effect of periostin on the function of osteoblasts and periodontal ligament cells, such as apoptosis and the associated signal pathway. In the result, it is revealed that periostin is associated with the apoptosis of periodontal ligament cells by the hypoxia-induced system, and the signaling pathway including FAK, JNK, ERK, P38 and AKT. Additionally, in the signaling pathway of β-catenin, periostin might affect the anti-apoptotic action in various cells.
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