• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the resorption of bone restrainer aiming at clinical application for the child steroid-related jawbone osteoporosis

Research Project

Project/Area Number 20592410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKyushu Dental College

Principal Investigator

MAKI Kenshi  Kyushu Dental College, 歯学部, 教授 (60209400)

Co-Investigator(Kenkyū-buntansha) JIMI eijiro  九州歯科大学, 歯学部, 教授 (40276598)
FUKUSHIMA Hidefumi  九州歯科大学, 歯学部, 助教 (70412624)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsステロイド / リセドロネート / 顎骨 / 破骨細胞 / 新生代ビスフォスフォネーと / 小児期 / p130Cas / アクチンリング / 骨粗鬆症 / 骨吸収抑制剤
Research Abstract

Gluocorticoids are used to treat various disease, such as severe asthma ,rheumatioid arthritis, and chronic renal disease,but the incidence rates. But the incidence rate of glucocorticoid-induced osteoporosis is approximately 50% in patients treated for 6 months or longer. In children,not only osteoporosis but also growth retaradation occurred with choronic glucocorticoid therapy.
However, little is known about the bone metabolism and bone architecture of the mandible with GC induced osteoporosis in children and adolescens. Bisphosphanate which are widely use to manage adluts with osteoporosis are divided into 2 classes according to their chemical structure and mechanism of action. The nitrogen-containing bisphosphonates ,such as risedoronate ,are markedly more potent inhibitors of osteoclastic bone resorption than nonnitrogen-containing bisphosphonates ,such as etidronate and clodronate. Hover,the effctts of nitrogen-containing bisphosphonates on bone structure and bone formation of the mandible in cases of established GC induced osteoporosis during the growth syage are unknown.
The aim of the present study was to estimate the effects of the tibia and mandible in growing rats treaed with t glucocorticoid (GC) 5-wwk-old male Wistar rats were given oral risedoronate were given oral in dose of (saline), 0.5, or 1.0mg/kg/day for 4 weeks following administration of oral predonisolone in dose of 30mg/kg/2days for 6 weeks.
In trabecular bone, risedronate improved the GC induced decreases in bone cross-sectional area and bone mineral content. Risedoronate increased bone density and also formed formed dense bone microarchitetecture by reducing in bone turn over rate. In cortical bone ,risedronate improved GC induced decreases in bone cross sectional area and bone mineral content.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Effects of risedronate on cortical and trabecular bone of the mandible in glucocorticoid-treated growing rats.2011

    • Author(s)
      Fujita Y, Watanabe K, Uchikanbori S, Maki K.
    • Journal Title

      Am J Orthod Dentofacial Orthop 139

      Pages: 267-277

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mineral Trioxide Aggregate inhibits osteoclastic bone resorption.2011

    • Author(s)
      Hashiguchi D, Fukushima H, Yasuda H, Masuda W, Tomikawa M. Morikawa K, Maki K, Jimi E.
    • Journal Title

      J Dent Res 90

      Pages: 912-917

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mineral trioxide aggregate solution inhibits osteoclast differentiation through the maintenance of osteoprotegerin expression in osteoblasts.2011

    • Author(s)
      Hashuguchi D, Fukushima H, Nakamura M, Morikawa K, Yasuda H, Udagawa N, Maki K, Jimi E.
    • Journal Title

      J Biomed Mater ResA 96

      Pages: 358-364

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of risedoronate on cortical and trabecular bone on the mandible in glucocorticoid-treated growing rats.2011

    • Author(s)
      Fujita Y, Watanabe K, Uchikanbori S, Maki K
    • Journal Title

      Am J Orthod Dentfacial Orthop

      Volume: 39 Pages: 267-277

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ビスフォスフォネートが小児期ステロイド性骨粗鬆症モデルラット脛骨の骨代謝回転に及ぼす影響2009

    • Author(s)
      長谷川薫、牧憲司
    • Journal Title

      九州歯会誌 63

      Pages: 32-43

    • NAID

      10025993261

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of restricted calcium intake on bone and maxillofacial growth2008

    • Author(s)
      Watanabe K,, Imamura H, Uchikanbori S, Fujita Y, Maki K.
    • Journal Title

      Angle Orthod 78

      Pages: 445-452

    • Related Report
      2010 Final Research Report
  • [Journal Article] Short-term etidoronate prevents glucocorticoid-induced bone debility of the mandible in growing rats.2008

    • Author(s)
      Fujita Y, Konoo T, Maki K
    • Journal Title

      Orthod Craniofacial Res 11

      Pages: 187-195

    • Related Report
      2010 Final Research Report
  • [Journal Article] Short-term etidronate treatment prevents glucocorticoid-induced bone debility of the mandible in growing rats.2008

    • Author(s)
      Fujita Y, Konoo T, Maki K
    • Journal Title

      Orthod Craniofac Res 11

      Pages: 187-95

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] MTAセメントは破骨細胞の分化の抑制と機能抑制により骨吸収を抑制する2010

    • Author(s)
      橋口大輔、福島秀文、森川和政、自見英治郎、牧憲司
    • Organizer
      第48回日本小児歯科学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 破骨細胞による骨吸収におけるp130CASの役割2010

    • Author(s)
      永井香絵、中村仁美、福島秀文、自見英治郎、牧憲司
    • Organizer
      日本小児歯科学会秋期大会
    • Place of Presentation
      郡山市
    • Related Report
      2010 Final Research Report
  • [Presentation] リセドロネートがステロイド性骨粗鬆症を惹起した成長期ラット脛骨の軟骨内骨化および膜性骨化に及す影響2009

    • Author(s)
      藤田優子、渡辺幸嗣、牧憲司
    • Organizer
      第47回日本小児歯科学会
    • Related Report
      2010 Final Research Report
  • [Presentation] MTAは破骨細胞の分化を抑制する2008

    • Author(s)
      橋口大輔、福島桂子、中尾加代子、福島秀文、自見英治郎, 牧憲司
    • Organizer
      第26回日本小児歯科学会九州地方会大会および総会
    • Place of Presentation
      沖縄
    • Year and Date
      2008-11-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 成長期ラット顎骨の骨動態にステロイドとビスフォスフォネートが及ぼす影響-組織形態計測および微細構造解析-2008

    • Author(s)
      藤田優子、野村信人、田窪二郎、内上堀伸作、渡辺幸嗣、牧憲司
    • Organizer
      第46回日本小児歯科学会
    • Place of Presentation
      埼玉
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi