| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
We attempted to isolate and culture of human dental epithelial stem cells and mesenchymal stem cells, and we examined the possibility of human tooth regeneration using these dental epithelial and mesenchymal stem cells. In order to investigate the possibility of tooth regeneration using these cells, we transplanted the recombinant dental lamina epithelial cells and dental papilla into the abdominal cavities of SCID mice. The epithelial cells had developed into dental epithelium resembling the bud stage. The present results suggest that human dental lamina cells are a useful source of dental epithelial stem cells for human tooth regeneration.
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