Basic and Clinical Studies of FGF Signaling at tooth and Plate Development
| Project/Area Number |
20592413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
TAKAMORI Kazunori Meikai University, 歯学部, 講師 (60256899)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | FGFシグナル / FGFR / 口蓋形成 / Kallmann症候群 / FRS2α / 歯牙形成 / FGF シグナル |
|---|
| Research Abstract |
Fgf signal was curial role of epithelial and mesenchymal tissue interaction on lung and limbs. However, it was not well understand of the tooth and palate development.
We evaluate of role of FGF epithelial and mesenchymal tissue interaction in the tooth and palate development by FGFR1 and R2 conditional knockout mouse, FRS2α knockout mouse, and Kallmann syndrome patient.
Obtain results suggested that FGF reciprocal tissue interaction was important role of both organ development and differentiation. These data was usefulness for search of a pathogenesis and establishment of therapy.
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Report
(4 results)
Research Products
(10 results)
