Biologic pathways for the relationship between periodontitis and cardiovascular disease

• Project/Area Number: 20592426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: TABETA Koichi Niigata University, 超域研究機構, 准教授 (20401763)
• Co-Investigator(Kenkyū-buntansha): 山崎 和久 新潟大学, 医歯学系, 教授 (00182478)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯周炎 / Porphyromonas gingivalis / エイジング / 動脈硬化症 / マウスモデル

Research Abstract

Periodontal infection itself does not cause atherosclerosis, but it accelerates it by inducing systemic inflammation and deteriorating lipid metabolism, particularly when underlying hyperlipidemia or susceptibility to hyperlipidemia exists, and it may contribute to the development of coronary heart disease. Further study is undertaken related to aging.

Research Products

• [Journal Article] Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile. (2011)
  • Author(s): Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, Miyazawa H, Nakajima T, Yamazaki K.
  • Journal Title: PLos One in press
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the up-regulation of early growth response-1 transcription in human coronary artery endothelial cells. (2010)
  • Author(s): Maekawa T, Takahashi N, Honda T, Yonezawa D, Miyashita H, Okui T, Tabeta K, Yamazaki K.
  • Journal Title: J Vase Res. 47 Pages: 346-354
  • Peer Reviewed
• [Journal Article] Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2. (2010)
  • Author(s): Aoki Y, Tabeta K, Murakami Y, Yoshimura F, Yamazaki K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 16;398(1) Pages: 86-91
  • Peer Reviewed
• [Journal Article] Interleukin-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. (2010)
  • Author(s): Takahashi N, Honda T, Domon H, Nakajima T, Tabeta K, Yamazaki K.
  • Journal Title: J Periodontal Res. Volume: Aug;45(4) Pages: 512-519
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis Antigens and Interleukin-6 Stimulate the Production of Monocyte Chemoattractant Protein-1 via the Upregulation of Early Growth Response-1 Transcription in Human Coronary Artery Endothelial Cells. (2009)
  • Author(s): Maekawa Tomoki
  • Journal Title: J Vasc Res. 16 ; 47(4) Pages: 346-354
  • Peer Reviewed
• [Journal Article] Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. (2009)
  • Author(s): Naka jima Takako
  • Journal Title: J Periodontal Res.
  • Peer Reviewed
• [Presentation] Apolipoprotein E欠損マウスにおけるPorphyromonas gingivalis長期感染後の血清脂質プロファイルの変化. (2010)
  • Author(s): 多部田康一
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] 動脈硬化自然発症モデルマウスにおけるPorphyromonas gingivalis長期感染後の血清脂質プロファイルの変化 (2010)
  • Author(s): 多部田康一
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] Porphyromonas gingivalis alters the serum lipid profile inmice. (2010)
  • Author(s): 多部田康一
  • Organizer: 88^<th> General Session of the IADR
  • Place of Presentation: Barcelona
  • Year and Date: 2010-07-17
• [Presentation] 動脈硬化自然発症モデルマウスにおけるPorphyromonas gingivalis長期感染後の血清脂質プロファイルの変化. (2010)
  • Author(s): 多部田康一
  • Organizer: 第132回日本歯科保存学会 2010年度春季学術大会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-06-04
• [Presentation] マウスPorphyromonas gingivalis口腔感染モデルにおける動脈硬化性変化の解析 (2010)
  • Author(s): 多部田康一
  • Organizer: 第2回口腔環境制御研究カテゴリー集会
  • Place of Presentation: 長崎市
  • Year and Date: 2010-02-10
• [Presentation] 歯周炎と動脈硬化性疾患 -関連メカニズムの解析- (2009)
  • Author(s): 多部田康一
  • Organizer: 日本歯周病学会第52回学術大会シンポジウム
  • Place of Presentation: 宮崎観光ホテル・宮崎市
  • Year and Date: 2009-10-11
• [Presentation] 歯周炎マウスモデルにおける口腔内感染が血清脂質、大動脈組織の遺伝子発現変化に与える影響-歯周炎が全身に与える影響のエビデンス (2008)
  • Author(s): 多部田 康一
  • Organizer: 第40回日本動脈硬化学会・学術集会
  • Place of Presentation: つくば国際会議場・つくば市
  • Year and Date: 2008-07-11
• [Remarks] ホームページ等
  • URL: http://www.dent.niigata-u.ac.jp/yamazaki_labo/