| Project/Area Number |
20592427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YANAGITA Manabu Osaka University, 大学院・歯学研究科, 助教 (80379081)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Satoru 大阪大学, 歯学部附属病院, 講師 (40359849)
HASHIKAWA Tomoko 大阪大学, 大学院・歯学研究科, 助教 (00362682)
SHIMABUKURO Yoshio 大阪大学, 大学院・歯学研究科, 准教授 (50231361)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周免疫機能学 / リゾリン脂質 / 歯肉線維芽細胞 / スフィンゴシン1リン酸 / IL-6 / ICAK-1 / スフィンゴシン-1-リン酸 / CD54 |
|---|
| Research Abstract |
In this study, we have investigated the effect of S1P on human gingival fibroblast (HGF). S1P upregulated to produce proinflammatory cytokine (IL-6 and IL-8) from HGF. Further, CD54 expression on HGF was induced by S1P in a dose-dependent manner. Antagonist of S1P2, one of the subsets of S1P receptor, reduced S1P-induced inflammatory cytokine production and CD54 expression on HGF. These findings indicate that S1P plays the important role as inflammatory mediator for establishment of periodontal disease.
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