Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients
| Project/Area Number |
20592428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
NARUISHI Koji Okayama University, 歯学部, 准教授 (00346446)
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| Co-Investigator(Kenkyū-buntansha) |
HATANAKA Kazu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (50362992)
TAKASHIBA Syougo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
MINESHIBA Junji 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00509383)
OMORI Kazuhiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20549860)
塩見 信行 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90432632)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖尿病 / MMP-3 / 歯周病悪化 / インターロイキン6 / マクロファージ / インターロイキン6レセプター / 歯肉線維芽細胞 / 糖尿病マウス / 歯周病悪化メカニズム |
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| Research Abstract |
Diabetic patients are susceptible to severe inflammatory periodontitis. In the present study, we found that high glucose increased MMP-3, but not sIL-6R production in gingival fibroblasts. In addition, sIL-6R production was suppressed by MMP-3 inhibitor in THP-1 macrophages. These results suggest that MMP-3 has a key role in developing severe periodontitis in diabetic patients. Furthermore, it has been considered that IL-6 signals are very important factor surrounding gingival fibroblasts/macrophage interaction in severe periodontitis seen in diabetic patients.
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Report
(4 results)
Research Products
(27 results)
