| Project/Area Number |
20592430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
SHIBA Hideki Hiroshima University, 病院, 講師 (60260668)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tsuyoshi 広島大学, 病院, 助教 (80379883)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Katsuhiro 広島大学, 大学院・医歯薬学総合研究科, 助教 (10452591)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | LL37 / 抗菌ペプチド / 歯周炎予防 / 歯周組織再生 / 血管新生 / 歯周療法学 |
|---|
| Research Abstract |
LL37, which has antibacterial activity against cariogenic and periodontopathogenic bacteria abolished the increase in the factor involved in inflammation induced by periodontopathogenic bacteria. LL37 enhanced the production of the factor involved in angiogenesis. Furthermore, LL37 promoted the new bone formation in the rat experimentally created calvarial bone defect. Thus, in addition to antibacterial activity, LL37 is found to possess anti-inflammatory action, angiogenic activity and osteogenic activity, suggesting LL37 is possible to be useful for prevention of periodontal disease and periodontal tissue regeneration.
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