| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Periodontal diseases are the inflammatory diseases caused by the bacteria in dental plaque. Since TLR2 and TLR4 play a central role in the recognition of bacterial products in periodontal tissue, we analyzed the ability of dental plaque to stimulate TLR2, 4. The ability of dental plaque to induce TLR4-mediated stimulation was positively associated with the clinical parameters at the sampled sites. The ability to induce TLR4-mediated stimulation was also associated with the levels of the cytokines produced by the peripheral blood mononuclear cells stimulated with the plaque. Endotoxins in the dental plaque possessed potent pro-inflammatory activities and measurement of the ability to induce TLR4-mediated stimulation would be useful for the evaluation of periodontal disease activity.
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