Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
Some of periodontal pathogens have an ability to invade gingival epithelial cells. This ability is thought as one of the mechanism to induce periodontal inflammation. In the present study, we focus on NOD proteins that have been shown to play an important role on detection and elimination of invasive bacteria, and investigate whether NODs proteins can recognize periodontal pathogens or not. As results, we find both NOD1- and NOD2-stimulatory activities are different by the species of periodontal pathogens.
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