Effects of Smoking and Passive Smoking in Oral Host Defense Functions.

• Project/Area Number: 20592437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: NUMABE Yukihiro The Nippon Dental University, 生命歯学部, 教授 (90198557)
• Co-Investigator(Kenkyū-buntansha): ITO Hiroshi 日本歯科大学, 生命歯学部, 准教授 (30184683) ; SUZUKI Asami 日本歯科大学, 生命歯学部, 助教 (60318540)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 唾液 / 能動喫煙 / 受動喫煙 / 好中球 / 生体防御

Research Abstract

The present study focused on the relationship between cigarette smoking (first and second hand smoking) and changes of various oral host defense functions in healthy or periodontitis patients. These findings suggest that the effect of smoking was enhanced in periodontitis patients and substances in cigarette smoke could impaired immunological functions (decreasing PMN functions and increasing enzyme activities which associated with tissue destruction) in the oral cavity in smokers or passive smokers.

Research Products

• [Journal Article] 歯肉溝滲出液中に反映される酸化型α1-antitrypsin測定の有用性について (2010)
  • Author(s): 伊藤弘、沼部幸博
  • Journal Title: 歯科人間ドック学会会誌 5巻 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Nicotine-induced CCN2 : from Smoking to Periodontal Fibrosis. (2010)
  • Author(s): Takeuchi H, Kubota S, Murakashi E, Zhou Y, Endo K, Takigawa M, Numabe Y
  • Journal Title: Journal of Dental Research Volume: 89 Pages: 83-89
  • Peer Reviewed
• [Journal Article] 歯肉溝滲出液中に反映される酸化型α1-antitrypsin測定の有用性について (2010)
  • Author(s): 伊藤弘、沼部幸博
  • Journal Title: 歯科人間ドック学会会誌 Volume: 5 Pages: 5-11
  • Peer Reviewed
• [Journal Article] 唾液中コチニン量測定による喫煙・受動喫煙検査の有用性-GCFエラスターゼ活性を一指標として- (2009)
  • Author(s): 伊藤弘、沼部幸博
  • Journal Title: 日本歯周病学会会誌 44巻 Pages: 260-268
  • NAID: 10027095811
  • Peer Reviewed
• [Journal Article] Development of a database and ontology for pathogenic pathways in periodontitis (2009)
  • Author(s): Suzuki A、Takai-Igarashi T、Numabe Y、Tanaka H
  • Journal Title: In Silico Biology vol.9 Pages: 233-243
  • Peer Reviewed
• [Journal Article] Effect ofTGF- β1 on CCN2/CTGF in human normal gingival fibroblasts and periodontal ligament cell (2009)
  • Author(s): Takeuchi H、Kubota S、Murakashi E、Fukada T、Hashimoto S、Takigawa M、Numabe Y
  • Journal Title: Journal of Periodontal Research vol.44 Pages: 161-169
  • Peer Reviewed
• [Journal Article] 唾液中コチニン量測定による喫煙・受動喫煙検査の有用性-GCFエラスターゼ活性を一指標として- (2009)
  • Author(s): 伊藤弘、沼部幸博
  • Journal Title: 日本歯周病学会会誌 51 Pages: 260-268
  • NAID: 10027095811
  • Peer Reviewed
• [Journal Article] Effect of TGF-ss1 on CCN2/CTGF in human normal gingival fibroblasts and periodontal ligament cell. (2009)
  • Author(s): Takeuchi H, Kubota S, Murakashi E, Fukada T, Hashimoto S, Takigawa M, Numabe Y
  • Journal Title: Journal of Periodontal Research 44 Pages: 161-169
  • Peer Reviewed
• [Journal Article] 介護老人福祉施設入居者における唾液中の歯周病関連細菌とその関連因子 (2008)
  • Author(s): 久野彰子、沼部幸博
  • Journal Title: 老年歯科医学 23巻 Pages: 12-20
  • NAID: 10025743159
  • Peer Reviewed
• [Journal Article] 介護老人福祉施設入居者における唾液中の歯周病関連細菌とその関連因子 (2008)
  • Author(s): 久野彰子
  • Journal Title: 老年歯科医学 23 Pages: 12-20
  • Peer Reviewed
• [Presentation] Fibrogenic effect of nicotine from smoking on human periodontal tissue (2010)
  • Author(s): Takeuchi H、Murakashi E、Kubota S、Tachibana M、Okabe M、Takigawa M、Numabe Y
  • Organizer: The 96^<th> Annual Meeting of American Academy of Periodontology in collaboration with the Japanese Society of Periodontorogy
  • Place of Presentation: Hawaii、USA
  • Year and Date: 2010-11-01
• [Presentation] Fibrogenic effect of nicotine from smoking on human periodontal tissue. (2010)
  • Author(s): Takeuchi H, Murakashi E, Kubota S, Tachibana M, Okabe M, Takigawa M, Numabe Y
  • Organizer: The 96^<th> Annual Meeting of American Academy of Periodontology in collaboration with the Japanese Society of Periodontorogy
  • Place of Presentation: Honolulu Convention Center (Hawaii USA)
  • Year and Date: 2010-11-01
• [Presentation] 短期間禁煙がGCFエラスターゼ活性と唾液成分におよぼす影響 (2009)
  • Author(s): 伊藤弘、沼部幸博
  • Organizer: 春季日本歯科保存学会
  • Place of Presentation: 熊本
  • Year and Date: 2009-06-04
• [Presentation] 喫煙および受動喫煙がGCFエラスターゼ活性におよぼす影響とくにインヒビター・複合体との関連性について- (2009)
  • Author(s): 伊藤弘、沼部幸博
  • Organizer: 春季日本歯周病学会
  • Place of Presentation: 岩手
  • Year and Date: 2009-05-14
• [Presentation] Relationshipbetween smoking and gingival fibrosis (2009)
  • Author(s): Takeuchi H、Murakashi E、Kubota S、Takigawa M、Numabe Y
  • Organizer: 12^<th> International Academy of Periodontology
  • Place of Presentation: Agra、India
  • Year and Date: 2009-04-18
• [Presentation] Relationship between smoking and gingival fibrosis. (2009)
  • Author(s): Takeuchi H, Murakashi E, Kubota S, Takigawa M, Numabe Y
  • Organizer: 12^<th> International Academy of Periodontology
  • Place of Presentation: Agra, India
  • Year and Date: 2009-04-18
• [Presentation] The Smoking Effect on GCF Elastase Activity (2008)
  • Author(s): 伊藤弘、沼部幸博
  • Organizer: The Fourth Sino-Japanese Conference on Stomatology
  • Place of Presentation: Xi'an(西安)China
  • Year and Date: 2008-09-28
• [Presentation] The Smoking Effect on GCF Elastase Activity. (2008)
  • Author(s): Hiroshi Ito
  • Organizer: The Fourth Sino-Japanese Conference on Stomatology
  • Place of Presentation: Xi' an China
  • Year and Date: 2008-09-28