| Project/Area Number |
20592438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
HORIE Hidenori Kanagawa Dental College, 歯学部, 客員教授 (80046135)
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| Co-Investigator(Kenkyū-buntansha) |
SASAGURI Kenichi 神奈川歯科大, 歯学部, 講師 (10235286)
HAMADA Nobushiro 神奈川歯科大, 歯学部, 教授 (20247315)
NOZAKI Naohito 神奈川歯科大, 歯学部, 講師 (70222198)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ガレクチンー1 / マクロファージ / 歯周病 / LPS,サイトカイン / 炎症 / 予防 / ガレクチン-1 / マクロフージ / LPS / サイトカイン |
|---|
| Research Abstract |
We established that galectin-1 mRNA is expressed in rat gingival tissues and also showed that galectin-1 mRNA significantly increased by the challenge with Porphyromonas gingivalis indicating galectin-1 may regulate oral inflammation. On the other hand, LPS (100 ng/ml) induced macrophages to upregulate mRNAs associated with a pro-inflammatory response, ie, interleukin-1β(IL-1β), interleukin -6 (IL-6), inducible nitric oxide synthase (iNOS). We show that oxidized galectin-1 application (10 ng/ml) to LPS-treated macrophages reduced the LPS-induced increase in pro-inflammatory mRNA expression. oxidized galectin-1 restricts the pro-inflammatory actions of LPS, and this protein could limit the negative effects of inflammation in periodontitis.
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