| Project/Area Number |
20592440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
|
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
YOSHINARI Nobuo Matsumoto Dental University, 歯学部, 教授 (20231699)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIDA Sachio 松本歯科大学, 歯学部, 助教 (90410422)
YOKOI Takamasa 松本歯科大学, 歯学部, 講師 (40469010)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周炎 / 心臓血管疾患 / 疾患モデル / 血清アミロイドA / サイトカイン / 動脈硬化症 / 歯周病 / バイオマーカー |
|---|
| Research Abstract |
The purpose of the present study concerning the relation between periodontitis and arteriosclerosis is to examine whether Serum Amyloid A : SAA could be a marker of atherosclerogenesis in homozygous ApoE deficient mice. In mice, periodontopathic IL-6 was inserted to intraperitoneal injection. SAA m-RNA level in liver, serum SAA level, and the atherosclerosis level were measured. In IL-6 injected group, serum SAA m-RNA level, SAA level in IL-6 were higher than PBS injected group, and the area rate of an atherosclerosis were increased. Therefore, we suggest that SAA increased by IL-6 stimulation made due to periodontitis could cause the onset to an atherosclerosis.
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