Prediction study of atherosclerosis by periodontal disease through serum amyloid A.
| Project/Area Number |
20592440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
YOSHINARI Nobuo Matsumoto Dental University, 歯学部, 教授 (20231699)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIDA Sachio 松本歯科大学, 歯学部, 助教 (90410422)
YOKOI Takamasa 松本歯科大学, 歯学部, 講師 (40469010)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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|---|
| Keywords | 歯周炎 / 心臓血管疾患 / 疾患モデル / 血清アミロイドA / サイトカイン / 動脈硬化症 / 歯周病 / バイオマーカー |
|---|
| Research Abstract |
The purpose of the present study concerning the relation between periodontitis and arteriosclerosis is to examine whether Serum Amyloid A : SAA could be a marker of atherosclerogenesis in homozygous ApoE deficient mice. In mice, periodontopathic IL-6 was inserted to intraperitoneal injection. SAA m-RNA level in liver, serum SAA level, and the atherosclerosis level were measured. In IL-6 injected group, serum SAA m-RNA level, SAA level in IL-6 were higher than PBS injected group, and the area rate of an atherosclerosis were increased. Therefore, we suggest that SAA increased by IL-6 stimulation made due to periodontitis could cause the onset to an atherosclerosis.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Detecting young Japanese adults with undetected low skeletal bone density using panoramic radiographs2011
Author(s)
A Taguchi, N Sugino, M Miki, Y Kozai, N Mochizuki, H Osanai, S Yamada, H Kuroiwa, T Fujiki, K Uchida, N Yoshinari, I Kasai
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Journal Title
Dentomaxillofacial Radiology 109
Pages: 154-159
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Peer Reviewed
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[Journal Article]2010
Author(s)
Yoshiko Ariji, Akira Taguchi, Shigemitsu Sakuma, Manabu Miki, Takayuki Asawa, Keiichi Uchida, Nobuo Yoshinari, Yuichiro Hiraiwa, Yoshitaka Kise, Masahiro Izumi, Munetaka Naitoh, Akitoshi Katsumata, Eiichiro Ariji
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Journal Title
Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 109
Pages: 908-916
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Peer Reviewed
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[Book] 最新の歯周外科手術をマスターしよう-基本から高度症例の応用まで-2010
Author(s)
稲垣幸司,三谷章雄,山本弦太,伊藤正満,菊池毅,石原裕一,野口俊英,石原磯子,上條博之,坂本浩,河谷和彦,吉成伸夫
Publisher
株式会社第一歯科出版(東京)
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