| Project/Area Number |
20592441
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Osaka Dental University |
|---|
Principal Investigator |
KAMADA Aiko Osaka Dental University, 歯学部, 准教授 (50140215)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Joji 大阪歯科大学, 歯学部, 教授 (80169094)
IKEO Takashi 大阪歯科大学, 歯学部, 教授 (40159603)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 再生医学 / 歯学 / 硬組織 / アディポカイン / アディポネクチン / 骨芽細胞 / マイクロアレイ / アディポネクチン受容体 / 合成ペプチド / siRNA |
|---|
| Research Abstract |
In order to apply adipocyte-derived biologically active molecules to tissue engineering, we investigated effect of adipocytokine on periodontal tissues. It was demonstrated that adiponectin, abundant adipocytokine, influenced to the tissues directly, and the failure of adiponectin action suppressed the progression of osteoblast differentiation. Therefore, low plasma adiponectin levels may cause not only insulin resistance and metabolic syndrome but also delay of bone formation.
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