| Project/Area Number |
20592443
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Hyogo College of Medicine |
|---|
Principal Investigator |
OHYAMA Hideki Hyogo College of Medicine, 医学部, 准教授 (90280685)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TERADA Nobuyuki 兵庫医科大学, 医学部, 教授 (50150339)
NAKASHO Keiji 兵庫医科大学, 医学部, 教授 (00217712)
YAMADA Naoko 兵庫医科大学, 医学部, 講師 (10319858)
YAMANEGI Koji 兵庫医科大学, 医学部, 講師 (00434944)
URADE Masahiro 兵庫医科大学, 医学部, 教授 (70104883)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | 歯肉線維芽細胞 / 樹状細胞 / ヘルパーT細胞 / クラスII HLA分子 / サイトカイン / クテスII HLA分子 / クラスIIHLA分子 |
|---|
| Research Abstract |
In the study to examine the effects of products from human gingival fibroblasts (HGF) activated by cross-linking HLA-II molecules on Th-cell response and differentiation, we found that Th cells exhibited a Th2-shifted phenotype after mixed lymphocyte reaction culture between naive T cells and allogeneic DCs in the presence of culture supernatant from HGF stimulated via HLA-DQ molecules. The regulation of Th2 polarization in Th-cells could be partially attributed to the activation of DCs being affected by PGE_2 produced from HGF stimulated via HLA-DQ.
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