| Project/Area Number |
20592453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KUBONIWA Masae Osaka University, 大学院・歯学研究科, 助教 (00303983)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Kazuhiko 大阪大学, 大学院・歯学研究科, 助教 (00346165)
SEKINE Shinichi 大阪大学, 大学院・歯学研究科, 助教 (70506344)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | バイオフイルム / プロテオミクス / 歯周病原性細菌 / 代謝経路 / ビタミンB / 歯周病 / プロテオーム / porphyromonas gingivalis / Fusobacterium nucleatum / Streptococcus gordonii / Porphyromonas gingivalis |
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| Research Abstract |
P.gingivalis can assemble into a heterotypic community with a middle colonizer F.nucleatum and an early colonizer S.gordonii, and that a community lifestyle provides physiologic support for P.gingivalis. 1156 P.gingivalis proteins, including 403 down-regulated and 89 up-regulated proteins, were detected qualitatively during comparison of the three species model community with P.gingivalis incubated alone under the same conditions. Significant decreases were seen in proteins involved in thiamine, cobalamin, and pyrimidine synthesis. These results indicate that a community lifestyle provides physiologic support for P.gingivalis.
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