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Development of a new tooth coating with anti-carious and anti-periodontitis properties by using nanoparticles of Calcium Titanate

Research Project

Project/Area Number 20592454
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionOkayama University

Principal Investigator

KISHIMOTO Etsuo  Okayama University, 大学院・医歯薬学総合研究科, 准教授 (20091316)

Co-Investigator(Kenkyū-buntansha) NAGAI Noriyuki  岡山大学, 名誉教授 (90085770)
NAGATSUKA Hitoshi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70237535)
TAKAGI Shin  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40116471)
TSUJIGIWA Hidetsugu  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70335628)
NAGAOKA Noriyuki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (70304326)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsチタン酸 / ナノ粒子 / 生体材料 / 齲蝕 / 歯周病 / 抗菌
Research Abstract

The objective of this study was the development of a new tooth coating method for prevention of caries and periodontitis by using calcium titanate nanoparticles. KUSA/A1 cells culture with CaTiO3-C showed good results for cell proliferation and differentiation. Furthermore, we have been able to produce CaTiO3-C with antibiotic properties that gave satisfying results against carious bacteria. We expected that this new coating material could be of a great utility in the future

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (7 results)

  • [Journal Article] Effect of CaTiO(3)-CaCO(3) prepared by alkoxide method on cell response.2010

    • Author(s)
      Rodriguez AP, Inoue M, Tanaka T, Miyake M, Sfer AM, Kishimoto E, Tsujigiwa H, Rivera RS, Nagatsuka H.
    • Journal Title

      J Biomed Mater Res A. 93(1)

      Pages: 297-303

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a new titanium coating material (CaTiO3-aC) prepared by thermal decomposition method on osteoblastic cell response.2010

    • Author(s)
      Inoue M, Rodriguez AP, Takagi T, Katase N, Kubota M, Nagai N, Nagatsuka H, Inoue M, Nagaoka N, Takagi S, Suzuki K.
    • Journal Title

      J Biomater Appl. 24(7)

      Pages: 657-672

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of CaTiO(3)-CaCO(3) prepared by alkoxide method on cell response.2010

    • Author(s)
      Rodriguez AP
    • Journal Title

      J Biomed Mater Res A.

      Volume: 93 Pages: 297-303

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of calcium hydroxide removal and the influence on the sealing ability of root canals.2010

    • Author(s)
      Li Y
    • Journal Title

      J Hard Tissue Biology.

      Volume: 19 Pages: 161-166

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a new titanium coating material(CaTiO3-aC)prepared by thermal decomposition method on osteoblastic cell response.2010

    • Author(s)
      Inoue M
    • Journal Title

      J Biomater Appl. 24

      Pages: 657-672

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant human bone morphogenetic protein-2/atelocollagen composite as a new material for ossicular reconstruction.2009

    • Author(s)
      Takeuchi A
    • Journal Title

      J Biomed Mater Res A. 89

      Pages: 36-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Analysis of a Novel Coating Material, CaTiO3-aC.2008

    • Author(s)
      Okauchi-Yabuuchi M, Tamamura R, Nagaoka N, Takagi S, Kishimoto E, Takagi T, Rodriguez A, Inoue M, Nagatsuka H, Akao M, Nagai N.
    • Journal Title

      Journal of Hard Tissue Biology. 17(3)

      Pages: 115-120

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Analysis of a Novel Coating Material, CaTiO_3-aC.2008

    • Author(s)
      Okauchi-Yabuuchi M
    • Journal Title

      Journal of Hard Tissue Biology 17

      Pages: 115-120

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Study about Tooth Size and Arch Width Measurement.2008

    • Author(s)
      Hong Q
    • Journal Title

      Journal of Hard Tissue Biology 17

      Pages: 91-98

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨髄幹細胞の歯・骨組織構成細胞への分化能についての検討2010

    • Author(s)
      辻極秀次
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規コーティング材CaTiO3-aCの細胞生物学的・組織学的検討2010

    • Author(s)
      平田泰久
    • Organizer
      第19回硬組織再生生物学会・学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規生体材料チタン酸カルシウム-炭酸カルシウム(CaTiO3-CaCO3)の細胞学的検討2009

    • Author(s)
      井上美穂
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] in vitro条件下において細胞外基質を産生する象牙芽幹細胞2009

    • Author(s)
      辻極秀次
    • Organizer
      第18回硬組織再生生物学会総会・学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of carbon in CaTiO_3 materials on cell proliferation and differentiation for medical application.2008

    • Author(s)
      A. Rodriguez
    • Organizer
      The 4th International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      Manila
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of carbon in CaTiO3 materials on cell proliferation and differentiation for medical application.2008

    • Author(s)
      A.Rodrigues
    • Organizer
      The 4th International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      Philippines
    • Year and Date
      2008-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] A preliminary comparative study of CaTiO_3 prepared by different methods.2008

    • Author(s)
      A. Rodriguez
    • Organizer
      第17回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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