Investigation of effect of soluble factors from adipose tissue on periodontitis, and development of prophylactic approach with these regulation
| Project/Area Number |
20592457
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
AKIFUSA Sumio Kyushu University, 歯学研究院, 准教授 (40295861)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Yoshihisa 九州大学, 大学院・歯学研究院, 教授 (20192403)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | メタボリックシンドローム / 歯周疾患 / 肥満 |
|---|
| Research Abstract |
We examined the effect of adiponectin, one of adipokine derived from mature adipocyte, on activity of macrophage, and found that administration of adiponectin reduced the lipopolysaccharide-induced inflammatory response. On the other hand, stimulation with adiponectin alone induced cytokine secretion, generation of reactive oxygen species and nitric oxide, followed by apoptotic cell death, in macrophage.
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Report
(4 results)
Research Products
(28 results)
