Experimental analysis of the induction mechanism of atherosclerosis by oral biofilm bacteria as a possible new risk factor
| Project/Area Number |
20592459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGATA Emi Kagoshima University, 医歯学総合研究科, 助教 (00304816)
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| Co-Investigator(Kenkyū-buntansha) |
OHO Takahito 鹿児島大学, 医歯学総合研究科, 教授 (50160940)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔細菌 / バイオフィルム / 感染症 / 動脈硬化 / 歯学 / 細菌 |
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| Research Abstract |
Oral viridans group streptococci are the major commensal bacteria of the supragingival oral biofilm and have been detected in human atheromatous plaque. The oral streptococci tested were capable of invading HAECs. HAECs invaded by one of four kinds of oral streptococci including cariogenic bacterium produced more cytokine(s) than non-invaded HAECs. These results suggest that oral streptococci may participate in the pathogenesis of atherosclerosis.
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Report
(4 results)
Research Products
(11 results)
