Experimental analysis of the induction mechanism of atherosclerosis by oral biofilm bacteria as a possible new risk factor

• Project/Area Number: 20592459
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Kagoshima University
• Principal Investigator: NAGATA Emi Kagoshima University, 医歯学総合研究科, 助教 (00304816)
• Co-Investigator(Kenkyū-buntansha): OHO Takahito 鹿児島大学, 医歯学総合研究科, 教授 (50160940)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔細菌 / バイオフィルム / 感染症 / 動脈硬化 / 歯学 / 細菌

Research Abstract

Oral viridans group streptococci are the major commensal bacteria of the supragingival oral biofilm and have been detected in human atheromatous plaque. The oral streptococci tested were capable of invading HAECs. HAECs invaded by one of four kinds of oral streptococci including cariogenic bacterium produced more cytokine(s) than non-invaded HAECs. These results suggest that oral streptococci may participate in the pathogenesis of atherosclerosis.

Research Products

• [Journal Article] Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production. (2011)
  • Author(s): Nagata E., de Toledo A., Oho T.
  • Journal Title: Mol.Oral Microbiol 26 Pages: 78-88
  • NAID: 110009668604
  • Peer Reviewed
• [Journal Article] Streptococcus anginosus L-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice. (2011)
  • Author(s): Takahashi Y., Yoshida A., Nagata E., Hoshino T., Oho T., Awano S., Takehara T., Ansai T.
  • Journal Title: Mol.Oral Microbiol in press
  • Peer Reviewed
• [Journal Article] Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production. (2011)
  • Author(s): Nagata E.
  • Journal Title: Mol.Oral Microbiol. Volume: 26 Pages: 78-88
  • NAID: 110009668604
  • Peer Reviewed
• [Journal Article] Streptococcus anginosus L-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice (2011)
  • Author(s): Takahashi Y.
  • Journal Title: Mol.Oral Microbiol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] 口腔バイオフィルムによる全身疾患の誘発 (2009)
  • Author(s): 長田恵美
  • Journal Title: 日本歯科評論 69 Pages: 157-159
  • Peer Reviewed
• [Presentation] ヒト動脈内内皮細胞に侵入した口腔レンサ球菌のサイトカイン産生誘導能の検討 (2010)
  • Author(s): 長田恵美, de Toledo A., 於保孝彦
  • Organizer: 第59回日本口腔衛生学会総会
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター(新潟県)
  • Year and Date: 2010-10-08
• [Presentation] ヒト動脈内内皮細胞に侵入した口腔レンサ球菌のサイトカイン産生誘導能の検討 (2010)
  • Author(s): 長田恵美
  • Organizer: 第59回日本口腔衛生学会・総会
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター(新潟県)
  • Year and Date: 2010-10-08
• [Presentation] Production of inflammatory cytokines by HAECs invaded by oral streptococci. (2010)
  • Author(s): Nagata E., de Toledo A., Oho T.
  • Organizer: 88th General Session & Exhibition of International Association for Dental Research
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2010-07-16
• [Presentation] Production of Inflammatory Cytokines by HAECs Invaded by Oral Streptococci (2010)
  • Author(s): Nagata E.
  • Organizer: 88^<th> General Session & Exhibition of the IADR
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-07-16
• [Presentation] 口腔レンサ球菌のヒト動脈内皮細胞への侵入および炎症反応誘導について (2009)
  • Author(s): 長田恵美, de Toledo A., 於保孝彦
  • Organizer: 第58回日本口腔衛生学会総会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2009-10-11
• [Presentation] 口腔レンサ球菌のヒト動脈内皮細胞への侵入および炎症反応誘導について (2009)
  • Author(s): 長田恵美
  • Organizer: 第58回日本口腔衛生学会・総会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2009-10-11