Development of protection for systemic and oral infection by control of oral microbes.
| Project/Area Number |
20592460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
YAMAGUCHI Taihei Kagoshima University, 医歯学総合研究科, 准教授 (80230358)
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| Co-Investigator(Kenkyū-buntansha) |
OHO TAKAHITO 鹿児島大学, 医歯学総合研究科, 教授 (50160940)
SOUTOME Sakiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (20325799)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔常在菌 / 唾液 / 凝集 / 付着 / 凝集素 / カルシウム / 口腔細菌 / バイオフィルム / 感染 / アルブミン / 常在菌 / レンサ球菌 / 日和見感染 / 感染予防 / 口腔常在細菌 / 初期付着 / 菌体凝集 / 唾液凝集素 / 付着阻害 |
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| Research Abstract |
Streptococcus intermedius is an oral commensal and a cause of systemic pyogenic disease. A part of the organism possessed curly-like fimbriae. Genomic analyses showed that the operon of the fimbriae was a typical pilus gene operon and constructed of at least 4 ORFs. A fimI was predicted to be the structural subunit encoding the 486-amino acid protein, FimI. Strains of the Streptococcus anginosus group containing the fimI gene were restricted to serotype g and untypable,. Knockout mutants within fimI did not participate in saliva-mediated aggregation either. The adherent activity of mutants toward plastic wells coated with salivary agglutinin was about 65% that of the parent strain.
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Report
(4 results)
Research Products
(7 results)
