| Project/Area Number |
20592461
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
SOH Inho Kyushu Dental College, 歯学部, 助教 (10285463)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
ANSAI Toshihiro 九州歯科大学, 歯学部, 准教授 (80244789)
AWANO Syuuji 九州歯科大学, 歯学部, 講師 (20301442)
YOSHIDA Akihiro 九州歯科大学, 歯学部, 助教 (20364151)
TAKATA Yutaka 九州歯科大学, 歯学部, 教授 (40163208)
SONOKI Kazuo 九州歯科大学, 歯学部, 准教授 (50316155)
INENAGA Kiyotoshi 九州歯科大学, 歯学部, 教授 (90131903)
TAKEHARA Tadamichi 九州歯科大学, 歯学部, 名誉教授 (00038879)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯周病 / ストレス評価 / 唾液検査 / QOL評価 / ホルモン |
|---|
| Research Abstract |
Recent studies have found a positive relationship between periodontitis and the hormones cortisol and dehydroepiandrosterone (DHEA). We investigated the associations between periodontitis and the cortisol and DHEA levels in elderly never-smokers and smokers. The cortisol and DHEA levels in saliva were determined, together with the probing depth (PD) and clinical attachment loss (CAL), in 171 subjects (85 males, 86 females). Smoking affected the cortisol and DHEA levels, which were significantly associated with severe PD and CAL in never-smokers. According to the ROC analysis, the respective cutoff values for cortisol and DHEA that gave the optimal sensitivity and specificity for detecting severe periodontitis were 2.06ng/mL and 60.24pg/mL for PD and 2.12ng/mL and 61.78pg/mL for CAL. An assessment of hormone levels may be a useful screening method for periodontitis, although its utility is limited to never-smokers.
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