Elucidation of relationship between indole produced in periodontopathogenic bacteria and periodontal disease
| Project/Area Number |
20592463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
YOSHIDA Yasuo Iwate Medical University, 歯学部, 准教授 (10315096)
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| Co-Investigator(Kenkyū-buntansha) |
岸 光男 岩手医科大学, 歯学部, 准教授 (60295988)
帖佐 直幸 岩手医科大学, 歯学部, 助教 (80326694)
中野 善夫 日本大学, 歯学部, 准教授 (80253459)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | インドール / 歯周病細菌 / バイオフィルム / トリプトファナーゼ |
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| Research Abstract |
To elucidate the molecular mechanism to produce indole in Porphyromonas gingivalis、Fusobacterium nucleatum, and Prevotella intermedia, we carried out the transcriptional analyses of tnaA encoding tryptophanase associated with indole production and enzymatic characterization of the purified protein. We also clarified induction of F. nucleatum biofilm formation by indole. In addition, tryptophan that is a substrate for indole production was also suggested to promote biofilm formation of the microorganism.
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Report
(4 results)
Research Products
(27 results)
