Development of Salivary Test to Assess Remineralization Potential

• Project/Area Number: 20592464
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Iwate Medical University
• Principal Investigator: INABA Daisuke Iwate Medical University, 歯学部, 准教授 (90146085)
• Co-Investigator(Renkei-kenkyūsha): KAKUTA Hatsue 岩手医科大学, 歯学部, 研究員 (20382624) ; YONEMITSU Masami 岩手医科大学, 歯学部, 教授 (80092451)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 歯学 / 食品 / 唾液 / 再石灰化 / 臨床検査 / スクリーニング / カルシウム / リン酸 / 検査 / QLF

Research Abstract

Comparison of salivary mineral contents (Ca and phosphate) and enamel reaction suggested that remineralization in enamel was dependent on salivary Caamounts significantly. High resolution Quantitative Light-Induced Fluorescence system(QLF-D) was developed for assessment and it was found that intensities of red fluorescencein hidden caries correlated well with histological caries depth, and R/G ratio of redfluorescence images correlated with ISDAS scores.

Research Products

• [Journal Article] Impact of Mineral Supplementation to Acidic Solutions on Enamel Erosion as Measured by QLF (2009)
  • Author(s): Inaba, D., Ishizuki, N., Yonemitsu, M.
  • Journal Title: Cariology Today 5 Pages: 16-18
• [Journal Article] Impact of Mineral Supplementation to Acidic Solutions on Enamel Erosion as Measured by QLF (2008)
  • Author(s): Inaba, D., Ishizuki, N., Yonemitsu, M.
  • Journal Title: Cariology Today 5(1) Pages: 16-18
• [Presentation] Quantitative aspects of the novel QLF system for erosive lesions. (2010)
  • Author(s): Warita S, Inaba D, de Josselin de Jong E, van der Veen M
  • Organizer: 88th General Session and Exhibition of IADR
  • Place of Presentation: バルセロナ国際会議場(スペイン)
  • Year and Date: 2010-07-16
• [Presentation] Red fluorescence detection from the Occlusal Aspect of Extracted Molars Related to Fluorescence Depth Profile (2010)
  • Author(s): D. Inaba, E. de Josselin de Jong, M.H. van der Veen
  • Organizer: 57th congress of the European Organization for Caries Research
  • Place of Presentation: Montpellier, France
  • Year and Date: 2010-07-09
• [Presentation] Red fluorescence detection from the Occlusal Aspect of Extracted Molars Related to Fluorescence Depth Profile (2010)
  • Author(s): D.Inaba, E.de Josselin de Jong, M.H.van der Veen
  • Organizer: 57th congress of the European Organization for Caries Research
  • Place of Presentation: Ecole superieure d' Agronomie(フランス)
  • Year and Date: 2010-07-09
• [Presentation] Quantification algorithm of occlusal caries for light-induced fluorescence images (2010)
  • Author(s): E.de Josselin de Jong, D.Inaba, M.H.van der Veen
  • Organizer: 57th congress of the European Organization for Caries Research
  • Place of Presentation: Ecole superieure d' Agronomie(フランス)
  • Year and Date: 2010-07-09
• [Presentation] Comparison of measurements between conventional QLF Pro and newly developed QLF-D (2010)
  • Author(s): S.Warita, D.Inaba, E.de Josselin de Jong, M.H.van der Veen
  • Organizer: 57th congress of the European Organization for Caries Research
  • Place of Presentation: Ecole superieure d' Agronomie(フランス)
  • Year and Date: 2010-07-09
• [Presentation] Inhibitory Effects of Phosphoryl Oligosaccharides of Calcium on Enamel Erosion as measured by Quantitative Light-induced Fluorescence (2009)
  • Author(s): Inaba, D., Ishizuki, N., Kamasaka, H., Yonemitsu, M.
  • Organizer: 56th Congress of the European Organisation for Caries Research
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-07-04
• [Presentation] Inhibitory Effects of Phosphoryl-Oligosaccharide Calcium(PO_<s->Ca) on Enamel Erosion as measured by Quantitative Light-induced Fluorescence (2009)
  • Author(s): Inaba, D., Ishizuki, N., Yonemitsu, M.
  • Organizer: 56th Annual Congress of the European Organisation for Caries Research(ORCA)
  • Place of Presentation: ブダペスト
  • Year and Date: 2009-07-04
• [Presentation] Impact of Mineral Supplementation to Acidic Solutions on Enamel Erosion (2008)
  • Author(s): Ishizuki, N., Inaba, D., Yonemitsu, M.
  • Organizer: 56th Annual Meeting of the Japanese Association for Dental Research (JADR)
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2008-11-30
• [Presentation] Distributions of Salivary Calcium and Phosphate among 5,304 Japanese Populations (2008)
  • Author(s): Inaba, D., Tamura K., Orisaka, M., Yonemitsu, M.
  • Organizer: 55th European Organisation for Caries Research (ORCA)
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2008-07-04
• [Presentation] Distributions of Salivary Calcium and Phosphate among 5, 304 Japanese Populations (2008)
  • Author(s): D. Inaba, T. Satoh, M. Yonemitsu
  • Organizer: 55^<th> ORCA Congress
  • Place of Presentation: オランダ
  • Year and Date: 2008-07-03
• [Book] 唾液(歯と口腔の健康(担当部分:ミネラル平衡における唾液の役割:う蝕,酸蝕症ならびに歯石の形成))原著第3版 東京 (2008)
  • Author(s): 稲葉大輔
  • Publisher: 医歯薬出版
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 口腔内観察装置 (2010)
  • Inventor(s): 稲葉大輔
  • Industrial Property Rights Holder: 岩手医科大学
  • Filing Date: 2010-06-29