| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Although it has been demonstrated that the periodontal disease pathogen Porphyromonas gingivalis is able to invade into various types of cell in the periodontal tissue including oral mucosal epithelial cells, there are few studies that examine whether the bacterial invasion contribute to the pathogenic mechanisms involved in the lead of the exacerbation of the disease. Then, we have investigated the effect of the bacterial invasion on the human mucosal epithelial cell line KB cells in this study. Therefore, this study showed that the bacterial invasion is able to induce the expression of IL-6 in the cells.
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