| Project/Area Number |
20592476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
RYO Koufuchi Tsurumi University, 歯学部, 助教 (10298268)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
MORITO Mitsuhiko 鶴見大学, 歯学部, 教授 (30089429)
MISHIMA Kenji 鶴見大学, 歯学部, 准教授 (50275343)
INOUE Hiroko 鶴見大学, 歯学部, 講師 (50367306)
YAMADA Hiroyuki 鶴見大学, 歯学部, 講師 (90267542)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ドライマウス / 口腔乾燥症 / 唾液 / 遺伝子 / 生活習慣病 |
|---|
| Research Abstract |
The objective of this study was to examine the assessment of genetic risk for dry mouth. The study population comprised 238 unrelated Japanese individuals (122xerostomia ; 116 healthy) who either outpatient clinic of Tsurumi University School of Dental Medicine. They all had the typical symptoms of dry mouth. Multivariable logistic regression analysis was significantly detected 6SNPs. A stepwise forward selection procedure has demonstrated that Hmoxl and CD36 genotypes significantly affected with he prevalence of dry mouth. Determination of the combined genotype for these genes may contribute to primary, personalized prevention of this condition.
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