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Prevention of stomatitis associated with cancer chemotherapy by rinsing and gargling with cevimeline hydeochroride hydrate solution

Research Project

Project/Area Number 20592529
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fundamental nursing
Research InstitutionFukuoka University

Principal Investigator

YOSHIKAWA Chizuko  Fukuoka University, 医学部, 講師 (60461539)

Co-Investigator(Kenkyū-buntansha) HARADA Hiroe  福岡大学, 医学部, 教授 (60380383)
NAKASHIMA Emiko  福岡大学, 医学部, 准教授 (30461536)
SUZAKI Shinobu  福岡大学, 医学部, 助手 (20469381)
YAMASHITA Chinami  福岡大学, 医学部, 助手 (30469382)
KAWAGUCHI Kazuko  福岡大学, 医学部, 助手 (40469383)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsがん化学療法 / セビメリン / 口内炎 / 予防 / 塩酸セビメリン / 口内炎予防効果
Research Abstract

We investigated the influence on oral mucosa directly from the patients who were to receive cancer chemotherapy. We examined first the features of stomatitis depending on the chemotherapy regimen. It showed that the patients experienced dry mouth first followed by taste disturbances and stomatitis. Then, we hypothesized that preventing dry mouth would preclude such patients from getting mucositis. Cevimeline hydeochroride hydrate (CHH) is a drug to stimulate saliva secretion which may be an ideal agent to prevent dryness of the mouth. Then we conducted the study in healthy individuals to investigate the effects and toxicity profiles of this agent. The amount of saliva was increased during and even after gargle with CHH with no discernible toxicity. Then, we performed a sequential study, i.e. the patients who received chemotherapy with CHH gargle for the first cycle and then with no CHH for the next cycle. It is suggested that gargle with CHH is a good candidate to prevent stomatitis in patients receiving cytotoxic chemotherapeutic agents.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 2009

All Presentation (7 results)

  • [Presentation] 外来がん化学療法を受ける患者のレジメン別の口腔粘膜障害の実態2011

    • Author(s)
      吉川千鶴子、原田広枝、中嶋恵美子、須崎しのぶ、山下千波、川口賀津子
    • Organizer
      第25回日本がん看護学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-02-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 外来がん化学療法を受ける患者のレジメン別の口腔粘膜障害の実態2011

    • Author(s)
      吉川千鶴子
    • Organizer
      第25回日本がん看護学会学術集会
    • Place of Presentation
      神戸市神戸国際会議場
    • Year and Date
      2011-02-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん化学療法における口腔ケアに関する研究-セビメリン含嗽が唾液分泌及ぼ影響-2010

    • Author(s)
      吉川千鶴子、原田広枝、中嶋恵美子、須崎しのぶ、山下千波、川口賀津子
    • Organizer
      第30回日本看護科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] がん化学療法における口腔ケアに関する研究-セビメリン含漱が唾液分泌に及ぼす影響-2010

    • Author(s)
      吉川千鶴子
    • Organizer
      第30回日本看護科学学会学術集会
    • Place of Presentation
      札幌市札幌コンベンションセンター
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん化学療法に伴う口腔粘膜障害の後ろ向き調査の検討2009

    • Author(s)
      吉川千鶴子、中嶋恵美子、須崎しのぶ、山下千波、川口賀津子
    • Organizer
      第35回日本看護研究学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] がん化学療法に伴う口腔粘膜障害の後ろ向き検討2009

    • Author(s)
      吉川千鶴子
    • Organizer
      第35回日本看護研究学会学術集会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん化学療法に伴う口腔粘膜障害の後ろ向き調査の検討2009

    • Author(s)
      古川千鶴子
    • Organizer
      第35回日本看護研究学会学術集会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜 確定
    • Year and Date
      2009-08-03
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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