Inhibitory effect of lactoferrin oral administration on infection with mouse cytomegarovirus.

• Project/Area Number: 20592607
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Lifelong developmental nursing
• Research Institution: Tokai University
• Principal Investigator: SHIMIZU Keiko Tokai University, 健康科学部, 教授 (20056302)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: ラクトフェリン / サイトメガロウイルス / 感染防御 / 経口感染 / マウスサイトメガロウイル / 経口摂取

Research Abstract

Lactoferrin is an iron-binding protein and has been demonstrated in milk, and has been reported to have a variety of biological functions. Lactoferiin injected intraperitoneally(ip) has exhibited the inhibitory effect on mouse cytomegarovirus ip infection in mice. In the present study, lactoferrin by oral administration exhibited inhibitory effect on oral infection with mouse cytomegalovirus.