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Role of phosphatidylinositols in the pathogenesis of severe respiratory failure

Research Project

Project/Area Number 20599003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionAkita University

Principal Investigator

IMAI Yumiko  Akita University, 大学院・医学系研究科, 教授 (50231163)

Co-Investigator(Renkei-kenkyūsha) SASAKI Takehiko  秋田大学, 大学院・医学系研究科, 教授 (50333365)
SASAKI Junko  秋田大学, 大学院・医学系研究科, 講師 (30333371)
TAKASUGA Shunsuke  秋田大学, 大学院・医学系研究科, 助教 (90375262)
EGUCHI Satoshi  秋田大学, 大学院・医学系研究科, 助教 (70457117)
OHTEKI Toshiaki  東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords集中治療 / 呼吸不全 / ウイルス感染症 / 細胞膜イノシトールリン脂質 / インフルエンザ / イノシトールリン脂質 / 急性呼吸不全
Research Abstract

The acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is triggered by various pathogenic conditions including sepsis, gastric acid aspiration, trauma, or infection with various viruses (SARS-coronavirus, H5N1 avian influenza, or novel swine-origin 2009 H1N1 influenza). No effective drugs have been proven to improve clinical outcomes in ARDS. Considering its high lethality and the threats of influenza pandemics, it is crucial to identify novel therapeutic targets for ARDS. In the present study, using mouse ICU model system, we examined the role of phosphatidylinositol pathway in the pathogenesis of ARDS. We found that endosomal PIs, in particular class III PI3-kinase was involved in the pathogenesis of ARDS with non-viral and viral origins.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (78 results)

All 2010 2009 2008 Other

All Journal Article (39 results) (of which Peer Reviewed: 29 results) Presentation (35 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Trilogy of ACE2 : a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.2010

    • Author(s)
      Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM.
    • Journal Title

      Pharmacol Ther. 128(1)

      Pages: 119-28

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010

    • Author(s)
      Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
    • Journal Title

      Cell. 141(1)

      Pages: 142-53

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.2010

    • Author(s)
      Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B.
    • Journal Title

      PLoS One. 22,5(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis.2010

    • Author(s)
      Imai Y, Kuba K, Ohto-Nakanishi T, Penninger JM.
    • Journal Title

      Circ J. 74(3)

      Pages: 405-10

    • NAID

      10025942941

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ARDS発症機序解明の新たな展開2010

    • Author(s)
      今井由美子
    • Journal Title

      最新医学 66

      Pages: 505-510

    • NAID

      40019717352

    • Related Report
      2010 Final Research Report
  • [Journal Article] 宿主システムからのウイルス病原性発現機構解明へのアプローチ2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      実験医学 28

      Pages: 2924-26

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新興ウイルス感染症におけるARDS発症2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      重症化の分子機構実験医学 28

      Pages: 2934-39

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新型インフルエンザによるLI/ARDSの特徴は?2010

    • Author(s)
      今井由美子
    • Journal Title

      救急・集中治療 22

      Pages: 1114-1119

    • Related Report
      2010 Final Research Report
  • [Journal Article] 重症型インフルエンザの病態生理2010

    • Author(s)
      今井由美子
    • Journal Title

      人工呼吸 27

      Pages: 62-69

    • Related Report
      2010 Final Research Report
  • [Journal Article] ACE2と呼吸器疾患2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      呼吸 9

      Pages: 1070-1074

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新型インフルエンザとacute respiratory distress syndrome(ARDS)2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      日本集中治療医学会誌 17

      Pages: 11-17

    • NAID

      10026278043

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino_acid transporters2010

    • Author(s)
      Imai Y, 他4名
    • Journal Title

      Pharmacol Ther.

      Volume: 128 Pages: 119-128

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function2010

    • Author(s)
      Imai Y, 他33
    • Journal Title

      Cel1

      Volume: 141 Pages: 142-153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.2010

    • Author(s)
      Imai Y, 他11
    • Journal Title

      PLoS One

      Volume: 22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme 2(ACE2)in disease pathogenesis2010

    • Author(s)
      Imai Y, 他3
    • Journal Title

      Circ J

      Volume: 74 Pages: 405-410

    • NAID

      10025942941

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARDS発症機所解明の新たな展開2010

    • Author(s)
      今井由美子
    • Journal Title

      最新医学

      Volume: 66 Pages: 505-510

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新型インフルエンザと acute respiratory distress syndrome(ARDS)2010

    • Author(s)
      今井由美子, 他2
    • Journal Title

      日本集中治療医学会誌

      Volume: 17 Pages: 11-17

    • NAID

      10026278043

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 宿主システムからのウイルス病原性発現機構解明へのアプローチ2010

    • Author(s)
      今井由美子, 他1
    • Journal Title

      実験医学

      Volume: 28 Pages: 2924-2926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新興ウイルス感染症におけるARDS発症、重症化の分子機構2010

    • Author(s)
      今井由美子, 他1
    • Journal Title

      実験医学

      Volume: 28 Pages: 2934-2939

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新型インフルエンザによるLI/ARDSの特徴は?2010

    • Author(s)
      今井由美子
    • Journal Title

      救急・集中治療

      Volume: 22 Pages: 1114-1119

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 重症型インフルエンザの病態生理2010

    • Author(s)
      今井由美子
    • Journal Title

      人工呼吸

      Volume: 27 Pages: 62-69

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACE2と呼吸器疾患2010

    • Author(s)
      今井由美子, 他1
    • Journal Title

      呼吸

      Volume: 29 Pages: 1070-1074

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function2010

    • Author(s)
      今井由美子, 他33
    • Journal Title

      Cell 141

      Pages: 142-153

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.2010

    • Author(s)
      今井由美子, 他11
    • Journal Title

      PLoS One 22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis2010

    • Author(s)
      今井由美子, 他3
    • Journal Title

      Circ J 74

      Pages: 405-410

    • NAID

      10025942941

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新型インフルエンザとacute respiratory distress syndrome(ARDS)2010

    • Author(s)
      今井由美子, 他2
    • Journal Title

      日本集中治療医学会誌 17

      Pages: 11-17

    • NAID

      10026278043

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further advances in immunity against highly pathogenic influenza viruses.2009

    • Author(s)
      今井由美子.
    • Journal Title

      European Infectious Disease. 3(1)

      Pages: 61-4

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of ACE2 in pulmonary2009

    • Author(s)
      Oudit GY, Imai Y, Kuba K, Scholey JW, Penninger JM.
    • Journal Title

      diseases--relevance for the nephrologist. 24(5)

      Pages: 1362-5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザによる呼吸2009

    • Author(s)
      今井由美子, 他
    • Journal Title

      不全の発症機構細胞 41(14)

      Pages: 8-11

    • Related Report
      2010 Final Research Report
  • [Journal Article] Further advances in immunity against highly pathogenic influenza viruses2009

    • Author(s)
      今井由美子, 他2名
    • Journal Title

      European Infectious Disease 3

      Pages: 61-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of ACE2 in pulmonary diseases--relevance for the nephrologist.2009

    • Author(s)
      今井由美子, 他4
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 1362-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザによる呼吸不全の発症機構2009

    • Author(s)
      今井由美子, 他2
    • Journal Title

      細胞 41

      Pages: 8-11

    • NAID

      110007564743

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新型インフルエンザの病型の理解2009

    • Author(s)
      今井由美子, 他2
    • Journal Title

      呼吸器ケア 7

      Pages: 72-78

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice.2008

    • Author(s)
      Imai Y, Kuba K, Penninger JM.
    • Journal Title

      Exp Physiol. 93(5)

      Pages: 543-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.2008

    • Author(s)
      Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.
    • Journal Title

      Cell. 18,133(2)

      Pages: 235-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of oxidative stress and toll like receptor 4 signaling as a key pathwav of acute lung injury2008

    • Author(s)
      Ilnai Y, (他23名)
    • Journal Title

      Cell 18

      Pages: 235-49

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice2008

    • Author(s)
      Imai Y, Kuba K, Penninger JM
    • Journal Title

      Experimental Physiology 93

      Pages: 543-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lessons from SARS : a new potential therapy for acute respiratory distress syndrome(ARDS)with angiotensin converting enzyme 2(ACE2)2008

    • Author(s)
      今井由美子、久揚敬司、Josef Peminger
    • Journal Title

      麻酔 57

      Pages: 302-10

    • NAID

      40015892279

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Toll様受容体4-TRIFを介した過剰免疫はH5N1インフルエンザウイルスによる呼吸不全を重症化させる2008

    • Author(s)
      今井由美子、久場敬司、Josef Penninger
    • Journal Title

      細胞工学 27

      Pages: 696-97

    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular pathogenesis of respiratory failure in influenza.2010

    • Author(s)
      今井由美子
    • Organizer
      BMB2010 Biochemistry and Molecular Biology
    • Place of Presentation
      神戸(シンポジウム)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular pathogenesis of respiratory failure in influenza2010

    • Author(s)
      Yumiko Imai
    • Organizer
      BMB2010 Biochemistry and Molecular Biology
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acute lung injury (ALI)/ARDS mediated by emerging respiratory virus infection.2010

    • Author(s)
      今井由美子
    • Organizer
      HKU-PASTEUR IMMUNOLOGY COURSE
    • Place of Presentation
      Hong Kong(招待講演)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Acute lung injury (ALI)/ARDS mediated by emerging respiratory virus infection2010

    • Author(s)
      Yumiko Imai
    • Organizer
      HKU-PASTEUR IMMUNOLOGY COURSE
    • Place of Presentation
      Hong Kong(招待講演)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新型インフルエンザ2010

    • Author(s)
      今井由美子
    • Organizer
      呼吸療法医学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脂質メタボロミクスからみえてきたインフルエンザ重症化機構2010

    • Author(s)
      今井由美子
    • Organizer
      適応医学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] インフルエンザによる重症呼吸不全の病態2010

    • Author(s)
      今井由美子
    • Organizer
      集中治療学会近畿地方会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-06-22
    • Related Report
      2010 Final Research Report
  • [Presentation] インフルエンザによる重症呼吸不全の病態2010

    • Author(s)
      今井由美子
    • Organizer
      集巾治療学会近畿地方会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hyper-response of innate immune system triggered by oxidative stress and oxidized phospholipids controls the severity of acute lung injury.2010

    • Author(s)
      今井由美子
    • Organizer
      Keystone symposia
    • Place of Presentation
      京都
    • Year and Date
      2010-06-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Hyper-response of innate immune system triggered by oxidative stress and oxidized phospholipids controls the severity of acute lung injury2010

    • Author(s)
      Yumiko Imai
    • Organizer
      Keystone symposia
    • Place of Presentation
      Kyoto, Jaoan
    • Year and Date
      2010-06-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical role of neuro-immune cross talk in pulmonary inflammation2010

    • Author(s)
      今井由美子, 他
    • Organizer
      薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Critical role of CXCL10/IFNγ-inducible protein-10(IP-10)in non-viral and viral ARDS2010

    • Author(s)
      今井由美子, 他
    • Organizer
      薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Loss of Apelin accelerates heart failure and fibrosis in myocardial infarction through renin-angiotensin system2010

    • Author(s)
      今井由美子, 他
    • Organizer
      薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of Not3 as a conserved regulator of heart function in genome-wide Drosophila screening2010

    • Author(s)
      今井由美子, 他
    • Organizer
      薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of TLR4 in influenza pathogenesis and ACE2 interventional therapy.2010

    • Author(s)
      今井由美子
    • Organizer
      Gordon conference satellite symposium ; Mechanisms of lung injury and immunomodulator interventions in influenza
    • Place of Presentation
      Ventura, USA(招待講演)
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性肺損傷の炎症病態-SARS/高病原性インフルエンザ-2009

    • Author(s)
      今井由美子
    • Organizer
      アレルギー学会(招待講演)
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高病原性インフルエンザの分子病態2009

    • Author(s)
      今井由美子
    • Organizer
      日本生化学会(招待講演)
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新型インフルエンザの病態生理的特性2009

    • Author(s)
      今井由美子
    • Organizer
      新型インフルエンザ重症例検討会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Toll様受容体の病態生理学-インフルエンザによる急性肺損傷における役割-2009

    • Author(s)
      今井由美子
    • Organizer
      関東・甲信越・東京麻酔科学会(招待講演)
    • Place of Presentation
      松本
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] リフレッシャーコース 肺保護戦略の背景2009

    • Author(s)
      今井由美子
    • Organizer
      関東・甲信越・東京麻酔科学会(招待講演)
    • Place of Presentation
      松本
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新型インフルエンザ2009

    • Author(s)
      今井由美子
    • Organizer
      秋田感染症研究会(招待講演)
    • Place of Presentation
      秋田
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hyper-response of the innate immune system in highly pathogenic influenza virus infection2009

    • Author(s)
      今井由美子
    • Organizer
      呼吸療法医学会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] レニンアンジオテンシン系と疾患分子病態2009

    • Author(s)
      今井由美子
    • Organizer
      日本循環器学会東北地方会(招待講演)
    • Place of Presentation
      盛岡
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザによる呼吸不全の病態と治療戦略2009

    • Author(s)
      今井由美子
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2009-06-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The role of ACE2 in the pathogenesis of ALI : a therapeutic perspective.2009

    • Author(s)
      今井由美子
    • Organizer
      Korean Critical Care Medicine
    • Place of Presentation
      Soul, Korea(招待講演)
    • Year and Date
      2009-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of ACE2 in the pathogenesis of ALI : a therapeutic perspective2009

    • Author(s)
      今井由美子
    • Organizer
      Korean Critical Care Medicine(招待講演)
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2009-04-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dysregulation of innate immune response and respiratory failure in highly pathogenic H5N1 avian influenza virus infection2009

    • Author(s)
      今井由美子
    • Organizer
      Surface Barrier Immunology Study Group(SBARIS)「Immune Response at Mucosa」Surfacei meeting
    • Place of Presentation
      東京
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高病原性インフルエンザウイルスによる過剰免疫応答と致死性呼吸不全の発症機構2009

    • Author(s)
      今井由美子
    • Organizer
      宮崎サイエンスキャンプ
    • Place of Presentation
      宮崎
    • Year and Date
      2009-02-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急性呼吸不全の分子病態2009

    • Author(s)
      今井由美子
    • Organizer
      HFO研究会
    • Place of Presentation
      諏訪
    • Year and Date
      2009-01-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高病原性H5N1鳥インフルエンザウイルスによる過剰免疫応答とARDSの発症機構2008

    • Author(s)
      今井由美子
    • Organizer
      日本産婦人科学会地方会
    • Place of Presentation
      秋田
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高病原性H5N1鳥インフルエンザウイルスによる過剰免疫応答とARDSの発症機構2008

    • Author(s)
      今井由美子
    • Organizer
      小児ICU学会
    • Place of Presentation
      軽井沢
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] The acid aspiration model of acute lung injury2008

    • Author(s)
      今井由美子
    • Organizer
      European Respiratory Society
    • Place of Presentation
      Berlin
    • Year and Date
      2008-10-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of oxidative stress and Toll like receptor 4 signaling as a key pathway of cvtokine storm in H5N1 avian influenza virus infection2008

    • Author(s)
      今井由美子
    • Organizer
      淡路感染症・免疫フォーラム
    • Place of Presentation
      淡路
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高病原性インフルエンザにおける重症呼吸不全と過剰免疫2008

    • Author(s)
      今井由美子
    • Organizer
      北東北血液研究会
    • Place of Presentation
      秋田
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 重症呼吸不全におけるToll様受容体4と酸化ストレスの病因的役割2008

    • Author(s)
      今井由美子
    • Organizer
      生命科学研究会
    • Place of Presentation
      別府
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Book] Pathogenesis of Ventilator-Induced Lung Injury, Physiological Basis of Ventilatory Support2009

    • Author(s)
      Valenza F, Frank JA, Imai Y, Slutsky AS.
    • Publisher
      Marcel Dekker Inc.
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.akita-u.ac.jp/~yakuri/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/'yakuri/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~yakuri/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-11-18  

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