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Differentiation of liver cancer stem cells

Research Project

Project/Area Number 20599005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKanazawa University

Principal Investigator

YAMASHITA Taro  Kanazawa University, 附属病院, 助教 (90377432)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords癌 / 発生・分化 / 幹細胞 / マイクロアレイ / 発現制御 / 肝細胞癌 / Oncostatin M / 抗癌剤感受性 / 細胞周期 / アポトーシス / 肝細胞分化シグナル / 抗癌剤抵抗性 / Wntシグナル
Research Abstract

Recent evidence suggests that tumor cells possess stem cell features (cancer stem cells) to self-renew and give rise to relatively differentiated cells through asymmetric division, thereby forming heterogeneous populations. Cancer stem cells are considered to be resistant to chemotherapy and radiotherapy, which might be associated with the recurrence of the tumor after treatment. Oncostatin M (OSM) is a pleiotropic cytokine known to activate the hepatocytic differentiation program in hepatoblasts in an OSMR-specific manner. We identified that OSMR is expressed in a subset of liver cancer stem cells and OSM induces hepatocytic differentiation of these cells. OSM-mediated hepatocytic differentiation effectively suppressed HCC growth when combined with conventional chemotherapy, suggesting the utility of OSM for the treatment of liver cancer stem cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (5 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Oncostatin mrenders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation.2010

    • Author(s)
      Yamashita T, et al
    • Journal Title

      Cancer Research 70

      Pages: 4687-4697

    • NAID

      120002220837

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncostatinm renders epithelial cell adhesion molecule-positive liver cancer stem cell ssensitive to 5-Fluorouracil by inducing hepatocytic differentiation2010

    • Author(s)
      Yamashita T, 他8名
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 4687-4697

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma2010

    • Author(s)
      Takatori H, Yamashita T, 他8名
    • Journal Title

      Liver International

      Volume: 30 Pages: 438-446

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression analysis of 5-end of mRNA identified novel in tronic transcripts associated with hepatocellular carcinoma2010

    • Author(s)
      HodoY, 他7名
    • Journal Title

      Genomics

      Volume: 95 Pages: 217-223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.2009

    • Author(s)
      Yamashita T, et al
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • NAID

      40016795576

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM^+ hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features2009

    • Author(s)
      Yamashita T., 他15名
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of MicroRNA-181 by Genome-Wide Screening as a Critical Player in EpCAM-Positive Hepatic cancer Stem Cells2009

    • Author(s)
      Ji J Yamashita T., 他14名
    • Journal Title

      Hepatology 50

      Pages: 472-480

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma2009

    • Author(s)
      Yamashita T., 他7名
    • Journal Title

      Journal of Hepatology 50

      Pages: 100-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM^+ hepatocellular carcinoma cells are tumor initiating t.ells with stem/progenitor cell features2009

    • Author(s)
      Yamashita T., 他15名
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in henatocellular carcinoma2009

    • Author(s)
      Yamashita T., 他7名
    • Journal Title

      Journal of Hepatology 50

      Pages: 100-110

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of Serial Analysis of Gene Expression in Cancer Research2008

    • Author(s)
      Yamashita T., 他2名
    • Journal Title

      Current Pharmaceutical Biotechnology 9

      Pages: 376-382

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Signaling pathways responsible for self-renewal and differentiation in liver cancer stem cells.2010

    • Author(s)
      Yamashita T, Honda M, Kaneko S.
    • Organizer
      Japanese Cancer Association 69^<th> Annual Meeting
    • Place of Presentation
      Osaka International Convention Center(Japan)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Signaling pathways responsible for self-renewal and differentiation in liver cancer stem cells.2010

    • Author(s)
      Yamashita T
    • Organizer
      日本癌学会学術総会(JCA annual meeting2010)
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oncostatin M renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation.2010

    • Author(s)
      Yamashita T, Honda M, Nio K, Kaneko S.
    • Organizer
      American Association for Cancer Research 101^<st> Annual Meeting.
    • Place of Presentation
      Walter E.Washington Convention Center(USA)
    • Year and Date
      2010-04-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Augmentation of hepatic cancer stem cells by Wnt/β-catenin signaling2009

    • Author(s)
      Yamashita T
    • Organizer
      AACR 2009 (アメリカ癌学会)
    • Place of Presentation
      Colorado Convention Center (Denver)
    • Year and Date
      2009-04-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bolstering hepatic cancer stem cells by wnt/beta-catenin signaling2008

    • Author(s)
      Yamashita T
    • Organizer
      アメリカ肝臓学会
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Book] In : Molecular Genetics of Liver Neoplasia.(Chapter 16.Heterogeneity of Liver Cancer Stem Cells.)2010

    • Author(s)
      Yamashita T, et al.
    • Publisher
      Springer New York
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-11-18  

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