Involvement ofsphingosine-1-phosphate (S1P) in the pathogenesis of preeclampsia

• Project/Area Number: 20599006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagoya University
• Principal Investigator: KOTANI Tomomi Nagoya University, 医学部附属病院, 講師 (70359751)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,000,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: EVT / 脱落膜 / SphK / 細胞浸潤 / LPA / 細胞侵潤

Research Abstract

The first step of the pathogenesis of preeclampsia is thought to be the failure of fetus extravillous trophoblasts (EVT) invasion into maternal desidua. It is suggested to be resulted in shallow placentaion, followed by intrauterine growth retardation. However, the molecular mechanisms remain unclear. In this study, we found that shingoshine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are main lysophospholipids known as a chemical mediator of cell proliferation and motility, would be involved in the invasion of EVT. These would be targets for the new therapy of preeclampsia.

Research Products

• [Journal Article] Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN). (2011)
  • Author(s): Tsuda H, Takahashi Y, Iwagaki S, Uchida Y, Kawabata I, Hayakawa M, Sumigama S, Hayakawa H, Kotani T, Kikkawa F.
  • Journal Title: J Perinat Med. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Successful fertility management of a patient with factor V deficiency : planned transfusion of fresh frozen plasma under infertility treatment. (2011)
  • Author(s): Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F.
  • Journal Title: Fertil Steril. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (2010)
  • Author(s): Kotani T, Sumigama S, Hayakawa H, Mano Y, Tsuda H, Sugiyama C, Kawachi F, Hironaka M, Kato T, Kaneko K, Hayakawa M, Kikkawa F.
  • Journal Title: Ultrasound Obstet Gynecol. 36(2) Pages: 256-258
  • Peer Reviewed
• [Journal Article] Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation. (2010)
  • Author(s): Tsuda H, Takahashi Y, Iwagaki S, Kawabata I, Hayakawa H, Kotani T, Shibata K, Kikkawa F.
  • Journal Title: J Matern Fetal Neonatal Med. 23(10) Pages: 1230-1236
  • Peer Reviewed
• [Journal Article] Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells. (2010)
  • Author(s): Morimitsu A, Sumigama S, Kotani T, Mano Y, Suzuki K, Araki-Taguchi M, Yamamoto E, Hayakawa H, Okada M, Itakura A, Kikkawa F.
  • Journal Title: Gynecol Obstet Invest. 69(1) Pages: 67-72
  • Peer Reviewed
• [Journal Article] Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line. (2009)
  • Author(s): Kotani T, Iwase A, Ino K, Sumigama S, Yamamoto E, Hayakawa H, Nagasaka T, Itakura A, Nomura S, Kikkawa F.
  • Journal Title: Endocrinology. 150(9) Pages: 4376-4385
  • Peer Reviewed
• [Presentation] 妊婦におけるCAVIの検討 (2010)
  • Author(s): 小谷友美, ら
  • Organizer: 第31回日本妊娠高血圧学会学術集会
  • Place of Presentation: 市ヶ谷(日本大学会館)
  • Year and Date: 2010-10-16
• [Presentation] リンパ管の異常形成を伴うPlacental Mesenchymaldysplasia (PMD)によりIUGRに至ったと考えられた1例 (2010)
  • Author(s): 小谷友美
  • Organizer: 第18回日本胎盤学会学術集会ならびに第28回日本絨毛性疾患研究会
  • Place of Presentation: 熊本(ホテル日航熊本)
  • Year and Date: 2010-10-01
• [Presentation] Marfan症候群合併妊娠で妊娠中にStanford B型急性大動脈解離をきたした1例 (2010)
  • Author(s): 小谷友美, ら
  • Organizer: 第33回日本母体胎児医学会学術集会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 2010-08-29
• [Presentation] 妊娠経過中に発見された腰骨骨肉腫の1例 (2010)
  • Author(s): 小谷友美, ら
  • Organizer: 第46回日本周産期・新生児医学会学術集会
  • Place of Presentation: 神戸(神戸国際会議場)
  • Year and Date: 2010-07-12
• [Presentation] Lysophosphatidic acidによる絨毛細胞の遊走作用 (2010)
  • Author(s): 小谷友美, ら
  • Organizer: 第62回日本産婦人科学会学術講演会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2010-04-25
• [Presentation] Lysophosphatidic acid(LPA)による絨毛細胞の遊走作用 (2010)
  • Author(s): 小谷友美
  • Organizer: 第62回日本産婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-25
• [Presentation] HTR-8/SVneo細胞機能におけるLPAの役割 (2009)
  • Author(s): 小谷友美, ら
  • Organizer: 第17回日本胎盤学会学術集会ならびに第27回日本絨毛性疾患研究会
  • Place of Presentation: 東京(東京ミッドタウン・カンファレンス)
  • Year and Date: 2009-10-17
• [Presentation] Lysophosphatidic acid regulated the migration of EVT cell line,HTR-8/SVneo (2009)
  • Author(s): 小谷友美, ら
  • Organizer: 15th IFPA Conference, workshop
  • Place of Presentation: Australia, Adelaide
  • Year and Date: 2009-10-07
• [Presentation] Lysophosphatidic acid regulated the migration of EVT cell line, HTR-8/S Vneo (2009)
  • Author(s): Tomomi Kotani
  • Organizer: 15^<th> IFPA Conference
  • Place of Presentation: Australia, Adelaide
  • Year and Date: 2009-10-07
• [Presentation] 転写因子AP-2は絨毛膜外絨毛細胞の浸潤は抑制する (2009)
  • Author(s): 小谷友美, ら
  • Organizer: 第30回日本妊娠高血圧学会学術集会
  • Place of Presentation: 岡山(岡山コンベンションセンター)
  • Year and Date: 2009-08-29
• [Presentation] 羊水過多,胎児心不全を呈したCongenital Mesoblastic Nephromaの2症例 (2009)
  • Author(s): 小谷友美, ら
  • Organizer: 第45回日本周産期・新生児医学会学術集会
  • Place of Presentation: 名古屋(名古屋国際会議場)
  • Year and Date: 2009-07-14
• [Presentation] 重篤な経過をたどった子宮内膜症合併妊娠の2例 (2009)
  • Author(s): 小谷友美, ら
  • Organizer: 第61回日本産婦人科学会学術講演会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2009-04-05
• [Presentation] スフィンゴシン1リン酸キナーゼの妊娠初期絨毛脱落膜系での発現について (2008)
  • Author(s): 小谷友美, ら
  • Organizer: 第16回日本胎盤学会学術集会ならびに第26回日本絨毛性疾患研究会
  • Place of Presentation: 浜松(アクトシテイ浜松コングレスセンター)
  • Year and Date: 2008-11-14
• [Presentation] スフィンゴシン1リン酸キナーゼの妊娠初期絨毛脱落膜系での発現について (2008)
  • Author(s): 小谷友美
  • Organizer: 第16回日本胎盤学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2008-11-01
• [Remarks] ホームページ等
  • URL: http://www.med.nagoya-u.ac.jp/obgy/research/obstetrics/
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/obgy/research/obstetrics/
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/obgy/research/obstetrics/