| Budget Amount *help |
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
It has been demonstrated that glycans on the cell surface was strongly involeved in malignant properties of oral squamous cell carcinomas and melanomas. Expression of Lewis y in oral squamous cell carcinomas resulted in attenuation of cancer malignant properties. As a mechanism, it was suggested that Lewis y might play roles in the negative regulation of the phosphorylation of EGFR. Furthermore, it was shown that majority of Yes was localized in GEM/rafts under GD3 expression in melanomas, resulting in the enhanced malignant properties by constitutive activation of Yes.
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