Mechanisms for the control of malignant properties of oral cacer with glyco-sphingolipids
| Project/Area Number |
20599007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
HAMAMURA Kazunori Nagoya University, 医学系研究科, 助教 (00422767)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 口腔扁平上皮癌 / メラノーマ / 糖脂質 / 糖タンパク質 / Lewis y / type 2H / ラフト / Srcファミリーキナーゼ / 血液型抗原 / ガングリオシド |
|---|
| Research Abstract |
It has been demonstrated that glycans on the cell surface was strongly involeved in malignant properties of oral squamous cell carcinomas and melanomas. Expression of Lewis y in oral squamous cell carcinomas resulted in attenuation of cancer malignant properties. As a mechanism, it was suggested that Lewis y might play roles in the negative regulation of the phosphorylation of EGFR. Furthermore, it was shown that majority of Yes was localized in GEM/rafts under GD3 expression in melanomas, resulting in the enhanced malignant properties by constitutive activation of Yes.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] GM1/GD1b/GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.2010
Author(s)
Yu Dong, *Kazutaka Ikeda, *Kazunori Hamamura, Qing Zhang, Yuji Kondo, Yasuyuki Matsumoto, Yuhsuke Ohmi, Yoshio Yamauchi, Keiko Furukawa, Ryo Taguchi, Koichi Furukawa.
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Journal Title
Cancer Sci.Review (+) *K.I. and K.H. contributed equally to this work. 101(9)
Pages: 2039-2047
NAID
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