Prevention and treatment of colorectal cancer by regulating macrophage activation.

• Project/Area Number: 20599008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: SENO Hiroshi Kyoto University, 医学研究科, 講師 (90335266)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,120,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: マクロファージ / 大腸癌 / 炎症 / マウス / M2 / 腫瘍 / 内視鏡 / ApcMin / 腸 / 癌

Research Abstract

During colorectal cancer progression, the interaction between cancer cells and stromal macrophages plays a crucial role. In this study, we demonstrated that interferon-gamma, which was regulated Trem2 or Cox-2, altered the activation status of tumor associated macrophages. Classically activated macrophages have a potential to inhibit cancer progression. We propose a novel therapeutic strategy against colorectal cancer by using activated macrophages.

Research Products

• [Journal Article] Multiple sexually transmitted infections. (2010)
  • Author(s): Nakanishi Y, Seno H, Chiba T, Yamashita Y.
  • Journal Title: J Gastoroenterol Hepatol. 25(4) Pages: 843-843
  • Peer Reviewed
• [Journal Article] Metastatic gastrointestinal stromal cell tumor mimicking gastrointestinal polyposis. (2010)
  • Author(s): Nakanishi Y, Kanda K, Akitake R, Seno H, Chiba T, Ono K, Kayahara T, Yamashita Y.
  • Journal Title: Endoscopy. 42 Suppl 2
  • Peer Reviewed
• [Journal Article] 胃ではLgr5陽性細胞が自己再生をにない、さらにこの細胞からin vitroで胃腺窩を長期間構築できた (2010)
  • Author(s): 上尾太郎、妹尾浩、千葉勉
  • Journal Title: 分子消化器病 7 Pages: 185-187
• [Journal Article] Multiple sexually transmitted infections. (2010)
  • Author(s): Nakanishi Y, Seno H, et al.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 25 Pages: 843-843
  • Peer Reviewed
• [Journal Article] Metstatic gastrointestinal stromal tumor mimicking gastrointestinal polyposis. (2010)
  • Author(s): Nakanishi Y, et al.
  • Journal Title: Endoscopy 42
  • Peer Reviewed
• [Journal Article] Perivascular epithelioid cell tumor (PEComa) of the liver diagnosed by contrast-enhanced ultrasonography. (2009)
  • Author(s): Akitake R, Kimura H, Sekoguchi S, Nakamura H, Seno H, Chiba T, Fujimoto S.
  • Journal Title: Intern Med. 48(24) Pages: 2083-6
  • Peer Reviewed
• [Journal Article] ポリポーシス症候群の遺伝子異常はどこまで解明されたか (2009)
  • Author(s): 妹尾浩、中西祐貴、秋武玲子、千葉勉
  • Journal Title: 分子消化器病 6 Pages: 262-267
• [Journal Article] Perivascular epithelioid cell tumor (PEComa) of the liver diagnosed by contrast-enhanced ultrasonography. (2009)
  • Author(s): Akitake R, et al.
  • Journal Title: Internal Medicine 48 Pages: 2083-2086
  • Peer Reviewed
• [Journal Article] ポリポーシス症候群の遺伝子異常はどこまで解明されたか (2009)
  • Author(s): 妹尾浩, ほか
  • Journal Title: 分子消化器病 6 Pages: 56-61
• [Presentation] Hes1は大腸腫瘍の増殖や未分化性の維持に重要である (2010)
  • Author(s): 上尾太郎、妹尾浩、仲瀬裕志
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] Hes1は大腸腫瘍の増殖や未分化能の維持に重要である (2010)
  • Author(s): 上尾太郎, 妹尾浩, 他
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] Hes not only regulates the proliferation and differentiation of colon stem cell but also keep stem cells at correct position. (2010)
  • Author(s): Ueo T, Seno H, Nakase H
  • Organizer: 1st International Topic Conference.
  • Place of Presentation: Kamakura, Japan
  • Year and Date: 2010-09-25
• [Presentation] Hes not only regulates the proliferation and differentiation of colon stem cell but also keep stem cells at correct position. (2010)
  • Author(s): Ueo T, Seno H, et al.
  • Organizer: International Topic Conference
  • Place of Presentation: Kamakura
  • Year and Date: 2010-09-25
• [Presentation] ナルディライジンによるIL-6/Stat3シグナルを介した胃癌細胞の増殖制御 (2010)
  • Author(s): 神田啓太郎、米門秀行、妹尾浩、千葉勉、西英一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Hes1は、大腸上皮幹細胞の分化や増殖を制御し、さらに幹細胞の位置や陰窩の形態保持に関与している (2010)
  • Author(s): 上尾太郎、妹尾浩、仲瀬裕志
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23
• [Presentation] 消化管上皮ならび腫瘍におけるHesの役割 (2009)
  • Author(s): 上尾太郎、妹尾浩、仲瀬裕志
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] マウス内視鏡を用いた新規大腸粘膜障害・再生モデルの検討 (2009)
  • Author(s): 秋武玲子、神田啓太郎、米門秀行、河田真由美、妹尾浩、千葉勉
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] マウス内神鏡を用いた新規大腸粘膜障害・再生モデルの検討 (2009)
  • Author(s): 秋武玲子, ほか
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-10-15
• [Presentation] Efficient colonic mucosal wound repair requires Trem2-dependent alternative activation of macrophages. (2009)
  • Author(s): Seno H.
  • Organizer: US-Japan GI Executive Meeting.
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2009-06-19
• [Book] pylori infection-The route from inflammation to cancer. Sansonetti P, ed, Infection Biology Handbook Series.Bacterial Virulence. Basic principles, models and global approaches. (2010)
  • Author(s): Chiba T, Marusawa H, Seno H, Watanabe N.H.
  • Publisher: Willey-Blackwell
• [Book] Bacterial Virulence. Basic principles, models and global approaches. (2010)
  • Author(s): Chiba T, Seno H, et al.
  • Total Pages: 11
  • Publisher: Willey-Blackwell