Prevention and treatment of colorectal cancer by regulating macrophage activation.
| Project/Area Number |
20599008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
SENO Hiroshi Kyoto University, 医学研究科, 講師 (90335266)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,120,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | マクロファージ / 大腸癌 / 炎症 / マウス / M2 / 腫瘍 / 内視鏡 / ApcMin / 腸 / 癌 |
|---|
| Research Abstract |
During colorectal cancer progression, the interaction between cancer cells and stromal macrophages plays a crucial role. In this study, we demonstrated that interferon-gamma, which was regulated Trem2 or Cox-2, altered the activation status of tumor associated macrophages. Classically activated macrophages have a potential to inhibit cancer progression. We propose a novel therapeutic strategy against colorectal cancer by using activated macrophages.
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Report
(4 results)
Research Products
(21 results)
