| Project/Area Number |
20599009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
SATOH Yusuke Osaka University, 医学系研究科, 助教 (20506307)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 医学系研究科, 助教 (20177489)
YOKOTA Takafumi 大阪大学, 医学系研究科, 助教 (60403200)
MAEDA Tetsuo 大阪大学, 医学系研究科, 助教 (00403064)
MATSUMURA Itaru 大阪大学, 医学系研究科, 准教授 (00294083)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 骨髄異形成症候群 / 急性骨髄性白血病 / AML1 / RUNX1 / DNA修復 / MDS / STAT5 |
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| Research Abstract |
We performed the functional analysis of AML1dC, which is a dominant negative mutant of AML1. As a result, we found that AML1dC enhances proliferating ability of hematopoietic stem/progenitor cells (HSPC ) and attenuates DNA repair ability of HSPC. Through these mechanisms, AML1dC promotes the development of myelodysplastic syndromes (MDS) and the transition from MDS to acute myeloid leukemia.
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