Analysis of autophagy in cancer and new strategies for cancer therapy.

• Project/Area Number: 20599013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kumamoto University
• Principal Investigator: HASHIMOTO Daisuke Kumamoto University, 医学部附属病院, 非常勤診療医師 (80508507)
• Co-Investigator(Kenkyū-buntansha): BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905) ; OHMURAYA Masaki 熊本大学, 大学院・先導機構, 特任助教 (60398229) ; TANAKA Hiroshi 熊本大学, 医学部附属病院, 非常勤診療医師 (70452901) ; SAKAMOTO Yasuo 熊本大学, 医学部附属病院, 医員 (00452897) ; OZAKI Nobuyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: オートファジー / 消化器癌の発生 / 消化器癌の発育 / 補助療法

Research Abstract

Autophagy was induced in pancreatic cancer cell line by anticancer agents and irradiation. Suppression of autophagy resulted in the augmentation of anticancer drug-induced cell death. This result suggested that autophagy might have the cytoprotective effect on anticancer drug-induced cell death in pancreatic cancer cell.

Research Products

• [Journal Article] Adult transmesenteric hernia : Report of two cases. (2011)
  • Author(s): Hashimoto D, Hirota M, Sakata K, Yagi Y, Baba, H.
  • Journal Title: Surgery Today (in press)
  • NAID: 10030621785
  • Peer Reviewed
• [Journal Article] Trichoblastic carcinoma arising from colostomy. (2011)
  • Author(s): Hashimoto D, Kuroki H, Motomura Y, Ishikawa S, Inayoshi A, Udaka N, Tanoue T, Arita T, Hiroto M, Yagi Y, Baba H.
  • Journal Title: Am J Surg (in press)
  • Peer Reviewed
• [Journal Article] Umbilicus Saving Three-Port Laparoscopic Cholecystectomy. (2011)
  • Author(s): Hashimoto D, Hirota M, Sakata K, Hirata K, Kiyota Y, Ishikawa S, Tanoue T, Inayoshi A, Arita T, Yagi Y, Baba, H.
  • Journal Title: WebmedCentral LAPAROSCOPY 2(4)
  • Peer Reviewed
• [Journal Article] 急性膵炎の発症とオートファジー機構 (2011)
  • Author(s): 廣田昌彦、橋本大輔、大村谷昌樹、山村研一
  • Journal Title: 消化器内科 52(2)
  • Peer Reviewed
• [Journal Article] 急性膵炎の発症とオートファジー機構 (2011)
  • Author(s): 廣田昌彦、橋本大輔, ら
  • Journal Title: 消化器内科 Volume: 52(2)
• [Journal Article] Detection of liver metastases secondary to pancreatic cancer : utility of combined helical computed tomography during arterial portography with biphasic computed tomography-assisted hepatic arteriography. (2010)
  • Author(s): Ikuta Y, Takamori H, Ikeda O, Tanaka T, Sakamoto Y, Hashimoto D, Ozaki N, Nakahara O, Furuhashi S, Abe S, Beppu T, Shimada S, Yamashita Y, Baba H.
  • Journal Title: J Gastroenterol 45(12) Pages: 1241-1246
  • NAID: 10027700141
  • Peer Reviewed
• [Journal Article] Is Estimation of physiologic ability and surgical stress (E-PASS) able to predict operative morbidity after pancreaticoduodenectomy? (2010)
  • Author(s): Hashimoto D, Takamori H, Sakamoto Y, Ikuta Y, Nakahara O, Furuhashi S, Tanaka H, Watanabe M, Beppu T, Hirota M, Baba H.
  • Journal Title: J Hepatobiliary Pancreat Sci. 17(2) Pages: 132-138
  • Peer Reviewed
• [Journal Article] Can the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy? (2010)
  • Author(s): Hashimoto D, Takamori H, Sakamoto Y, Tanaka H, Hirota M, Baba H.
  • Journal Title: Surgery Today 40(7) Pages: 632-637
  • Peer Reviewed
• [Journal Article] Acute afferent loop necrosis after Roux-en-Y cholangiojejunostomy (2010)
  • Author(s): Hashimoto D, Arita T, Kuroki H, Motomura Y, Ishikawa S, Inayoshi A, Udaka N, Tanoue T, Hiroto M, Yagi Y, Baba H.
  • Journal Title: Clin J Gastroenterol. 3(3) Pages: 165-167
  • NAID: 120003163927
  • Peer Reviewed
• [Journal Article] 急性膵炎の発症とオートファジー (2010)
  • Author(s): 廣田昌彦、大村谷昌樹、橋本大輔, ら
  • Journal Title: Annual Review消化器 Volume: 1 Pages: 212-217
• [Journal Article] Significance of Endothelial Molecular Markers in the Severity Evaluation of Acute Pancreatitis. (2009)
  • Author(s): Ida S, Fujiyama Y, Hirota M, Imamura Y, Ozaki N, Suyama K, Hashimoto D, Ohmuraya M, Tanaka H, Takamori H, Baba H.
  • Journal Title: Surg Today. 39(4) Pages: 314-319
  • Peer Reviewed
• [Journal Article] Gastric metastasis of malignant fibrous histiocytoma diagnosed preoperatively by endoscopic ultrasound-guided fine-needle aspiration biopsy : Report of a case. (2009)
  • Author(s): Hashimoto D, Watanabe M, Hayashi N, Nakahara O, Hirashima K, Iyama KI, Baba H.
  • Journal Title: Surgery Today. 39(12) Pages: 1073-1075
  • NAID: 10027393291
  • Peer Reviewed
• [Journal Article] Effect of low-molecular-weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells. (2009)
  • Author(s): Hashimoto D, Ohmuraya M, Wang J, Yamamura K, Hiroa M, Baba H.
  • Journal Title: Pancreas 38(5) Pages: 595-597
  • Peer Reviewed
• [Journal Article] A case of locally advanced rectal cancer responding to FOLFOX. (2009)
  • Author(s): Kume S, Kubota T, Takahashi M, Hashimoto D, Hirata T, Torigoe Y, Ikeda O.
  • Journal Title: Gan To Kagaku Ryoho. Japanese. 36(4) Pages: 659-661
  • Peer Reviewed
• [Journal Article] 急性膵炎の発症における細胞内イベント (2009)
  • Author(s): 廣田昌彦、橋本大輔、大村谷昌樹、馬場秀夫
  • Journal Title: 肝・胆・膵(0389-4991) 59(2) Pages: 165-167
  • Peer Reviewed
• [Journal Article] 膵腺房細胞内のトリプシン活性とプロテアーゼインヒビター (2009)
  • Author(s): 橋本大輔、大村谷昌樹、広田昌彦、高森啓史、山村研一、馬場秀夫
  • Journal Title: Surgery Frontier 16巻1号 Pages: 114-119
  • Peer Reviewed
• [Journal Article] Significance of Endothelial Molecular Markers in the Evaluation of Acute Pancreatitis (2009)
  • Author(s): Ida S
  • Journal Title: Surg Today 39 Pages: 314-319
  • Peer Reviewed
• [Journal Article] Effect of low-molecular weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells (2009)
  • Author(s): Hashimoto D
  • Journal Title: Surg Todaay 39 Pages: 1073-1075
  • Peer Reviewed
• [Journal Article] 膵腺細胞内のトリプシン活性とプロテアーゼインビター (2009)
  • Author(s): 橋本大輔
  • Journal Title: Surg Frontier 16 Pages: 114-119
  • Peer Reviewed
• [Journal Article] 膵腺細胞内のトリプシン活性とプロテアーゼインヒビター (2009)
  • Author(s): 橋本大輔
  • Journal Title: Surgery Frontier 16 Pages: 114-119
• [Journal Article] Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. (2008)
  • Author(s): Hashimoto D, Ohmuraya M, Hirota M, Yamamoto A, Suyama K, Ida S, Okumura Y, Takahashi E, Kido H, Araki K, Baba H, Mizushima N, Yamamura K.
  • Journal Title: J Cell Biol. 30;181(7) Pages: 1065-1072
  • Peer Reviewed
• [Journal Article] 遺伝子改変マウスを用いた膵炎の発症機構の解析 (2008)
  • Author(s): 大村谷昌樹, 広田昌彦, 橋本大輔, 馬場秀夫
  • Journal Title: 膵臓(0913-0071) 23巻1号 Pages: 20-24
  • NAID: 10024367316
  • Peer Reviewed
• [Journal Article] Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells (2008)
  • Author(s): Hashimoto D
  • Journal Title: J Cell Biol. 181 Pages: 1065-1072
  • Peer Reviewed
• [Journal Article] Effect of low-molecular-weight trypsin inhibitor, nafamostat mesilate, on trypsin activity within the pancreatic acinar cells
  • Author(s): Hashimoto D
  • Journal Title: Pancreas (in press)
  • Peer Reviewed
• [Presentation] 臍温存3ポート腹腔鏡下胆嚢摘除術 (2011)
  • Author(s): 橋本大輔
  • Organizer: 熊本外科治療講演会
  • Place of Presentation: 熊本市熊本大学
  • Year and Date: 2011-02-01
• [Presentation] 厚生労働科学研究(がん臨床研究)推進事業研究成果等一般向け発表会膵癌治療の最前線 (2011)
  • Author(s): 橋本大輔
  • Organizer: 手術と化学療法
  • Place of Presentation: 熊本市熊本県立劇場
  • Year and Date: 2011-01-08
• [Presentation] 人工肛門部に発生し術前に下行結腸癌と診断した、毛嚢由来の皮膚癌(trichoblastic carcinoma)の一例 (2010)
  • Author(s): 橋本大輔
  • Organizer: 第8回日本消化器外科学会大会横浜市
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-10-16
• [Presentation] 絞扼性イレウス74例の手術経験から (2010)
  • Author(s): 橋本大輔
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関市 下関市民会館
  • Year and Date: 2010-07-14
• [Presentation] Pancreatic acinar cell death pathways in acute pancreatitis. (2010)
  • Author(s): Ohmuraya M
  • Organizer: Joint meeting of the international association of pancreatology and the Japan pancreas society 2010
  • Place of Presentation: 福岡市 福岡国際会議場
  • Year and Date: 2010-07-12
• [Presentation] Pancreatic acinar cell death pathways in acute pancreatitis. (2010)
  • Author(s): Ohmuraya M, et al.
  • Organizer: Joint meeting of the international association of pancreatology and the Japan pancreas society 2010
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-07-12
• [Presentation] A mouse line expressing Spink3-driven Cre recombinase. (2010)
  • Author(s): Ohmuraya M
  • Organizer: The 42nd Meeting of the European Pancreatic Club
  • Place of Presentation: スウェーデンストックホルム市Clarion Sign Hotel
  • Year and Date: 2010-06-18
• [Presentation] A mouse line expressing Spink3-driven Cre recombinase. (2010)
  • Author(s): Ohmuraya M, et al.
  • Organizer: The 42nd Meeting of the European Pancreatic Club
  • Place of Presentation: Hudding & Clarion Hotel Sign(スウェーデンストックホルム市)
  • Year and Date: 2010-06-18
• [Presentation] 急性膵炎における栄養管理 (2010)
  • Author(s): 橋本大輔
  • Organizer: 熊本大学消化器外科学術講演会
  • Place of Presentation: 熊本市熊本大学
  • Year and Date: 2010-04-28
• [Presentation] 摂食、絶食が急性膵炎に及ぼす影響 (2010)
  • Author(s): 橋本大輔
  • Organizer: 第35回九州代謝・栄養研究会
  • Place of Presentation: 熊本市熊本大学
  • Year and Date: 2010-03-06
• [Presentation] Can the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predict operative morbidity after pancreatic resection? (2009)
  • Author(s): 橋本大輔
  • Organizer: 40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society
  • Place of Presentation: ホノル ルヒルトンハワイアンビレッジアメリカ
  • Year and Date: 2009-11-06
• [Presentation] 脾温存尾側膵切除に対するE-PASSスコアリングシステムを用いた術後合併症の解析 (2009)
  • Author(s): 橋本大輔
  • Organizer: 第64回日本消化器外科学会総会ワークショップ「尾側膵切除における脾温存の適応と成績」
  • Place of Presentation: 大阪市大阪国際会議場
  • Year and Date: 2009-07-18
• [Presentation] 慢性膵炎モデルの炸製とその解析 (2009)
  • Author(s): 井田智
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪 大阪国際会議場
  • Year and Date: 2009-07-17
• [Presentation] Autophagy process activates trypsinogen and the development of acute pancreatitis (2009)
  • Author(s): Hirota Masahiko
  • Organizer: The 41st European Meeting of the European Pancreatic Club
  • Place of Presentation: Hungary Congress Centre
  • Year and Date: 2009-07-03
• [Presentation] E-PASS (Estimation of physiologic ability and surgical stress)スコアリングシステムは膵体尾部切除術後合併症の発生予測に有用である (2009)
  • Author(s): 橋本大輔
  • Organizer: 第21回日本肝胆膵外科学会・学術集会サージカルフォーラム
  • Place of Presentation: 名古屋市ウエスティンナゴヤキャッスル
  • Year and Date: 2009-06-11
• [Presentation] 膵癌に対する集学的治療施行例における早期死亡率の検討 (2009)
  • Author(s): 高森啓史
  • Organizer: 第21回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 愛知 ウェスティンナゴヤキャッスル
  • Year and Date: 2009-06-11
• [Presentation] 膵頭十二指腸切除術に対するE-PASS scoring systemによるリスク評価 (2009)
  • Author(s): 橋本大輔
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡市マリンメッセ福岡
  • Year and Date: 2009-04-04
• [Presentation] 膵癌に肘る集学的治療施行例における長期生存の条件 (2009)
  • Author(s): 高森啓史
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2009-04-03
• [Presentation] 急性膵炎におけるオートファジーの誘導と食餌の影響 (2008)
  • Author(s): 橋本大輔
  • Organizer: 第39回日本膵臓学会大会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2008-07-30
• [Presentation] 高齢化社会における外科手術後合併症発生の抑制に対する取り組みの有用性について (2008)
  • Author(s): 橋本大輔
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌市札幌市教育文化会館
  • Year and Date: 2008-07-17
• [Presentation] 膵腺房細胞内のトリプシン活性に対するnafamostat mesilate (FUT)の抑制効果 (2008)
  • Author(s): 橋本大輔
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎市長崎新聞文化ホール
  • Year and Date: 2008-05-15
• [Presentation] 膵腺房細胞内のトリプシン活性に対するメシル酸ナファモスタットの抑制効果 (2008)
  • Author(s): 橋本大輔
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-05-15
• [Book] Laparoscopy(Laparoscopy-assisted distal pancreatectomy.) (2011)
  • Author(s): Hirota M, Hashimoto D, Sakata K, Kuroki H, Tanaka Y, Ishiko T, Motomura Y, Ishikawa S, Kiyota Y, Arita T, Inayoshi A, Yagi Y.
  • Publisher: published by InTech(Australia).(in press)
• [Book] 消化器(急性膵炎の発症とオートファジー) (2010)
  • Author(s): 廣田昌彦、大村谷昌樹、橋本大輔、馬場秀夫
  • Publisher: Annual Review
• [Book] 急性膵炎の病態生理新しい診断と治療のABC膵炎・膵癌54(8) (2008)
  • Author(s): 広田昌彦, 大村谷昌樹, 橋本大輔, 陶山浩一, 市原敦史, 藤村美憲, 田中洋, 高森啓史, 馬場秀夫
  • Publisher: 最新医学社
• [Book] 新しい診断と治療のABC膵炎・膵癌(54巻8号Page16-24) (2008)
  • Author(s): 広田昌彦
  • Total Pages: 9
  • Publisher: 最新医学社