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Analysis of autophagy in cancer and new strategies for cancer therapy.

Research Project

Project/Area Number 20599013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKumamoto University

Principal Investigator

HASHIMOTO Daisuke  Kumamoto University, 医学部附属病院, 非常勤診療医師 (80508507)

Co-Investigator(Kenkyū-buntansha) BABA Hideo  熊本大学, 大学院・生命科学研究部, 教授 (20240905)
OHMURAYA Masaki  熊本大学, 大学院・先導機構, 特任助教 (60398229)
TANAKA Hiroshi  熊本大学, 医学部附属病院, 非常勤診療医師 (70452901)
SAKAMOTO Yasuo  熊本大学, 医学部附属病院, 医員 (00452897)
OZAKI Nobuyuki  熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsオートファジー / 消化器癌の発生 / 消化器癌の発育 / 補助療法
Research Abstract

Autophagy was induced in pancreatic cancer cell line by anticancer agents and irradiation. Suppression of autophagy resulted in the augmentation of anticancer drug-induced cell death. This result suggested that autophagy might have the cytoprotective effect on anticancer drug-induced cell death in pancreatic cancer cell.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (52 results)

All 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 21 results) Presentation (24 results) Book (4 results)

  • [Journal Article] Adult transmesenteric hernia : Report of two cases.2011

    • Author(s)
      Hashimoto D, Hirota M, Sakata K, Yagi Y, Baba, H.
    • Journal Title

      Surgery Today (in press)

    • NAID

      10030621785

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trichoblastic carcinoma arising from colostomy.2011

    • Author(s)
      Hashimoto D, Kuroki H, Motomura Y, Ishikawa S, Inayoshi A, Udaka N, Tanoue T, Arita T, Hiroto M, Yagi Y, Baba H.
    • Journal Title

      Am J Surg (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Umbilicus Saving Three-Port Laparoscopic Cholecystectomy.2011

    • Author(s)
      Hashimoto D, Hirota M, Sakata K, Hirata K, Kiyota Y, Ishikawa S, Tanoue T, Inayoshi A, Arita T, Yagi Y, Baba, H.
    • Journal Title

      WebmedCentral LAPAROSCOPY 2(4)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性膵炎の発症とオートファジー機構2011

    • Author(s)
      廣田昌彦、橋本大輔、大村谷昌樹、山村研一
    • Journal Title

      消化器内科 52(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性膵炎の発症とオートファジー機構2011

    • Author(s)
      廣田昌彦、橋本大輔, ら
    • Journal Title

      消化器内科

      Volume: 52(2)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Detection of liver metastases secondary to pancreatic cancer : utility of combined helical computed tomography during arterial portography with biphasic computed tomography-assisted hepatic arteriography.2010

    • Author(s)
      Ikuta Y, Takamori H, Ikeda O, Tanaka T, Sakamoto Y, Hashimoto D, Ozaki N, Nakahara O, Furuhashi S, Abe S, Beppu T, Shimada S, Yamashita Y, Baba H.
    • Journal Title

      J Gastroenterol 45(12)

      Pages: 1241-1246

    • NAID

      10027700141

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is Estimation of physiologic ability and surgical stress (E-PASS) able to predict operative morbidity after pancreaticoduodenectomy?2010

    • Author(s)
      Hashimoto D, Takamori H, Sakamoto Y, Ikuta Y, Nakahara O, Furuhashi S, Tanaka H, Watanabe M, Beppu T, Hirota M, Baba H.
    • Journal Title

      J Hepatobiliary Pancreat Sci. 17(2)

      Pages: 132-138

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Can the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy?2010

    • Author(s)
      Hashimoto D, Takamori H, Sakamoto Y, Tanaka H, Hirota M, Baba H.
    • Journal Title

      Surgery Today 40(7)

      Pages: 632-637

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute afferent loop necrosis after Roux-en-Y cholangiojejunostomy2010

    • Author(s)
      Hashimoto D, Arita T, Kuroki H, Motomura Y, Ishikawa S, Inayoshi A, Udaka N, Tanoue T, Hiroto M, Yagi Y, Baba H.
    • Journal Title

      Clin J Gastroenterol. 3(3)

      Pages: 165-167

    • NAID

      120003163927

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性膵炎の発症とオートファジー2010

    • Author(s)
      廣田昌彦、大村谷昌樹、橋本大輔, ら
    • Journal Title

      Annual Review消化器

      Volume: 1 Pages: 212-217

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Significance of Endothelial Molecular Markers in the Severity Evaluation of Acute Pancreatitis.2009

    • Author(s)
      Ida S, Fujiyama Y, Hirota M, Imamura Y, Ozaki N, Suyama K, Hashimoto D, Ohmuraya M, Tanaka H, Takamori H, Baba H.
    • Journal Title

      Surg Today. 39(4)

      Pages: 314-319

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastric metastasis of malignant fibrous histiocytoma diagnosed preoperatively by endoscopic ultrasound-guided fine-needle aspiration biopsy : Report of a case.2009

    • Author(s)
      Hashimoto D, Watanabe M, Hayashi N, Nakahara O, Hirashima K, Iyama KI, Baba H.
    • Journal Title

      Surgery Today. 39(12)

      Pages: 1073-1075

    • NAID

      10027393291

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of low-molecular-weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells.2009

    • Author(s)
      Hashimoto D, Ohmuraya M, Wang J, Yamamura K, Hiroa M, Baba H.
    • Journal Title

      Pancreas 38(5)

      Pages: 595-597

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of locally advanced rectal cancer responding to FOLFOX.2009

    • Author(s)
      Kume S, Kubota T, Takahashi M, Hashimoto D, Hirata T, Torigoe Y, Ikeda O.
    • Journal Title

      Gan To Kagaku Ryoho. Japanese. 36(4)

      Pages: 659-661

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性膵炎の発症における細胞内イベント2009

    • Author(s)
      廣田昌彦、橋本大輔、大村谷昌樹、馬場秀夫
    • Journal Title

      肝・胆・膵(0389-4991) 59(2)

      Pages: 165-167

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膵腺房細胞内のトリプシン活性とプロテアーゼインヒビター2009

    • Author(s)
      橋本大輔、大村谷昌樹、広田昌彦、高森啓史、山村研一、馬場秀夫
    • Journal Title

      Surgery Frontier 16巻1号

      Pages: 114-119

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Endothelial Molecular Markers in the Evaluation of Acute Pancreatitis2009

    • Author(s)
      Ida S
    • Journal Title

      Surg Today 39

      Pages: 314-319

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of low-molecular weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells2009

    • Author(s)
      Hashimoto D
    • Journal Title

      Surg Todaay 39

      Pages: 1073-1075

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵腺細胞内のトリプシン活性とプロテアーゼインビター2009

    • Author(s)
      橋本大輔
    • Journal Title

      Surg Frontier 16

      Pages: 114-119

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵腺細胞内のトリプシン活性とプロテアーゼインヒビター2009

    • Author(s)
      橋本大輔
    • Journal Title

      Surgery Frontier 16

      Pages: 114-119

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells.2008

    • Author(s)
      Hashimoto D, Ohmuraya M, Hirota M, Yamamoto A, Suyama K, Ida S, Okumura Y, Takahashi E, Kido H, Araki K, Baba H, Mizushima N, Yamamura K.
    • Journal Title

      J Cell Biol. 30;181(7)

      Pages: 1065-1072

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子改変マウスを用いた膵炎の発症機構の解析2008

    • Author(s)
      大村谷昌樹, 広田昌彦, 橋本大輔, 馬場秀夫
    • Journal Title

      膵臓(0913-0071) 23巻1号

      Pages: 20-24

    • NAID

      10024367316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells2008

    • Author(s)
      Hashimoto D
    • Journal Title

      J Cell Biol. 181

      Pages: 1065-1072

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of low-molecular-weight trypsin inhibitor, nafamostat mesilate, on trypsin activity within the pancreatic acinar cells

    • Author(s)
      Hashimoto D
    • Journal Title

      Pancreas (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 臍温存3ポート腹腔鏡下胆嚢摘除術2011

    • Author(s)
      橋本大輔
    • Organizer
      熊本外科治療講演会
    • Place of Presentation
      熊本市熊本大学
    • Year and Date
      2011-02-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 厚生労働科学研究(がん臨床研究)推進事業研究成果等一般向け発表会膵癌治療の最前線2011

    • Author(s)
      橋本大輔
    • Organizer
      手術と化学療法
    • Place of Presentation
      熊本市熊本県立劇場
    • Year and Date
      2011-01-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 人工肛門部に発生し術前に下行結腸癌と診断した、毛嚢由来の皮膚癌(trichoblastic carcinoma)の一例2010

    • Author(s)
      橋本大輔
    • Organizer
      第8回日本消化器外科学会大会横浜市
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 絞扼性イレウス74例の手術経験から2010

    • Author(s)
      橋本大輔
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関市 下関市民会館
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Pancreatic acinar cell death pathways in acute pancreatitis.2010

    • Author(s)
      Ohmuraya M
    • Organizer
      Joint meeting of the international association of pancreatology and the Japan pancreas society 2010
    • Place of Presentation
      福岡市 福岡国際会議場
    • Year and Date
      2010-07-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Pancreatic acinar cell death pathways in acute pancreatitis.2010

    • Author(s)
      Ohmuraya M, et al.
    • Organizer
      Joint meeting of the international association of pancreatology and the Japan pancreas society 2010
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] A mouse line expressing Spink3-driven Cre recombinase.2010

    • Author(s)
      Ohmuraya M
    • Organizer
      The 42nd Meeting of the European Pancreatic Club
    • Place of Presentation
      スウェーデンストックホルム市Clarion Sign Hotel
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] A mouse line expressing Spink3-driven Cre recombinase.2010

    • Author(s)
      Ohmuraya M, et al.
    • Organizer
      The 42nd Meeting of the European Pancreatic Club
    • Place of Presentation
      Hudding & Clarion Hotel Sign(スウェーデンストックホルム市)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性膵炎における栄養管理2010

    • Author(s)
      橋本大輔
    • Organizer
      熊本大学消化器外科学術講演会
    • Place of Presentation
      熊本市熊本大学
    • Year and Date
      2010-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性膵炎における栄養管理2010

    • Author(s)
      橋本大輔
    • Organizer
      熊本大学消化器外科学術講演会
    • Place of Presentation
      熊本大学
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 摂食、絶食が急性膵炎に及ぼす影響2010

    • Author(s)
      橋本大輔
    • Organizer
      第35回九州代謝・栄養研究会
    • Place of Presentation
      熊本市熊本大学
    • Year and Date
      2010-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Can the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predict operative morbidity after pancreatic resection?2009

    • Author(s)
      橋本大輔
    • Organizer
      40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society
    • Place of Presentation
      ホノル ルヒルトンハワイアンビレッジアメリカ
    • Year and Date
      2009-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 脾温存尾側膵切除に対するE-PASSスコアリングシステムを用いた術後合併症の解析2009

    • Author(s)
      橋本大輔
    • Organizer
      第64回日本消化器外科学会総会ワークショップ「尾側膵切除における脾温存の適応と成績」
    • Place of Presentation
      大阪市大阪国際会議場
    • Year and Date
      2009-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性膵炎モデルの炸製とその解析2009

    • Author(s)
      井田智
    • Organizer
      第64回日本消化器外科学会総会
    • Place of Presentation
      大阪 大阪国際会議場
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Autophagy process activates trypsinogen and the development of acute pancreatitis2009

    • Author(s)
      Hirota Masahiko
    • Organizer
      The 41st European Meeting of the European Pancreatic Club
    • Place of Presentation
      Hungary Congress Centre
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] E-PASS (Estimation of physiologic ability and surgical stress)スコアリングシステムは膵体尾部切除術後合併症の発生予測に有用である2009

    • Author(s)
      橋本大輔
    • Organizer
      第21回日本肝胆膵外科学会・学術集会サージカルフォーラム
    • Place of Presentation
      名古屋市ウエスティンナゴヤキャッスル
    • Year and Date
      2009-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵癌に対する集学的治療施行例における早期死亡率の検討2009

    • Author(s)
      高森啓史
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      愛知 ウェスティンナゴヤキャッスル
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵頭十二指腸切除術に対するE-PASS scoring systemによるリスク評価2009

    • Author(s)
      橋本大輔
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡市マリンメッセ福岡
    • Year and Date
      2009-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵癌に肘る集学的治療施行例における長期生存の条件2009

    • Author(s)
      高森啓史
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡 福岡国際会議場
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性膵炎におけるオートファジーの誘導と食餌の影響2008

    • Author(s)
      橋本大輔
    • Organizer
      第39回日本膵臓学会大会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2008-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性膵炎におけるオートファジーの誘導と食餌の影響2008

    • Author(s)
      橋本大輔
    • Organizer
      第39回日本膵臓学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-07-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高齢化社会における外科手術後合併症発生の抑制に対する取り組みの有用性について2008

    • Author(s)
      橋本大輔
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌市札幌市教育文化会館
    • Year and Date
      2008-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵腺房細胞内のトリプシン活性に対するnafamostat mesilate (FUT)の抑制効果2008

    • Author(s)
      橋本大輔
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎市長崎新聞文化ホール
    • Year and Date
      2008-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵腺房細胞内のトリプシン活性に対するメシル酸ナファモスタットの抑制効果2008

    • Author(s)
      橋本大輔
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Book] Laparoscopy(Laparoscopy-assisted distal pancreatectomy.)2011

    • Author(s)
      Hirota M, Hashimoto D, Sakata K, Kuroki H, Tanaka Y, Ishiko T, Motomura Y, Ishikawa S, Kiyota Y, Arita T, Inayoshi A, Yagi Y.
    • Publisher
      published by InTech(Australia).(in press)
    • Related Report
      2010 Final Research Report
  • [Book] 消化器(急性膵炎の発症とオートファジー)2010

    • Author(s)
      廣田昌彦、大村谷昌樹、橋本大輔、馬場秀夫
    • Publisher
      Annual Review
    • Related Report
      2010 Final Research Report
  • [Book] 急性膵炎の病態生理新しい診断と治療のABC膵炎・膵癌54(8)2008

    • Author(s)
      広田昌彦, 大村谷昌樹, 橋本大輔, 陶山浩一, 市原敦史, 藤村美憲, 田中洋, 高森啓史, 馬場秀夫
    • Publisher
      最新医学社
    • Related Report
      2010 Final Research Report
  • [Book] 新しい診断と治療のABC膵炎・膵癌(54巻8号Page16-24)2008

    • Author(s)
      広田昌彦
    • Total Pages
      9
    • Publisher
      最新医学社
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-11-18  

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