| Project/Area Number |
20599015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
INAGAKI Kyoko University of the Ryukyus, 発達生理学研究系, 特任助教 (70363588)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Goro 琉球大学, 熱帯生物圏研究センター, 教授 (30229455)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 腸管上皮間T細胞 / 腸管上皮バリア / 腸管寄生細菌 / ジャンクション分子 / サイトカイン / 腸管感染性細菌 / サルモネラ / 腸管バリア / 上皮細胞 / IEL |
|---|
| Research Abstract |
The intestinal epithelium has evolved structurally to form a barrier between the antigen-rich environment of the lumen and the sterile internal environment of the organism. In this study, we demonstrated that IEL has an important role in early protection against intestinal infection by S. typhimurium and DSS-induced colitis which the escape immediate early protection at the surface of intestinal epithelia. These results indicate that IEL play important multifunctional roles not only in protection of the epithelium against S. typhimurium or DSS-induced change by cytokine production but also in direct interaction with the epithelial barrier when intra-EC junctions are down-regulated.
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