Significance of novel protein kinase in muscle function and disease
| Project/Area Number |
20599016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nara Medical University |
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Principal Investigator |
NAKAGAWA Osamu Nara Medical University, 医学部, 教授 (40283593)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Hisaki 奈良県立医科大学, 先端医学研究機構生命システム医科学分野循環器システム医科学研究室, 助教 (30533715)
SAKABE Masahide 奈良県立医科大学, 先端医学研究機構生命システム医科学分野循環器システム医科学研究室, 助教 (00525983)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,910,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 転写調節因子 / リン酸化酵素 / 筋肉 / 骨格筋疾患 |
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| Research Abstract |
Transcription factors regulate the expression levels of various downstream genes as "molecular switches" in our body. In order to clarify the importance of transcription factors, it is crucial to identify and characterize those downstream genes. In this context, we searched for the genes regulated by muscle-specific transcription factors and identified SRPK3 to be a muscle-specific gene encoding a novel protein kinase. Both deficiency and excess of SRPK3 activity in mice caused muscle abnormalities, indicating importance of proper regulation of SRPK3 function. In vivo significance and mechanisms of action of SRPK3 were further studied using various molecular biology techniques and mouse models.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.2008
Author(s)
Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H.
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Journal Title
Related Report
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